Functional role of T-type calcium channels in tumour growth and progression: prospective in cancer therapy

被引：49
作者：
Santoni, Giorgio [1 ]
Santoni, Matteo [2 ]
Nabissi, Massimo [1 ]
机构：
[1] Univ Camerino, Sch Pharm, Sect Expt Med, I-62018 Camerino, MC, Italy
[2] Univ Ancona, Dept Med Oncol, Ancona, Italy
来源：
BRITISH JOURNAL OF PHARMACOLOGY | 2012年 / 166卷 / 04期
关键词：
voltage-gated calcium channels; calcium; T-type calcium channels; mibefradil; endostatin; cell proliferation; invasion; tumour progression; gliomas; CA2+ CHANNEL; CELL-PROLIFERATION; EXPRESSION; ACTIVATION;
D O I：
10.1111/j.1476-5381.2012.01908.x
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
T-type Ca2+ channels represent a specific channel family overexpressed in different types of tumours. Their involvement in controlling the proliferation, angiogenesis and invasion of tumour cells, has been partially clarified. The article by Zhang . in this issue of BJP provides the first evidence of anti-tumoural effects of endostatin (ES) in U87 glioma cells. He demonstrated that ES or mibefradil (a L/T-type calcium channel blocker), reduces the proliferation and migration of U87 glioma cells in a T-type Ca2+ channel-dependent manner. However, the difference in the blocking effect of mibefradil on T-type calcium channel expression as compared with its ability to inhibit proliferation and migration, supports the idea of a broader T/L-type-independent effect of the mibefradil blocker. Overall, these findings provide new insights for the future development of a novel class of anti-T-type calcium channel blockers in the therapy of glioblastoma. LINKED ARTICLE This article is a commentary on Zhang et al., pp. 12471260 of this issue. To view this paper visit
引用
收藏
页码：1244 / 1246
页数：3
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