Parotid gland volumetric changes during intensity-modulated radiotherapy in head and neck cancer

被引：42

作者：

Fiorentino, A. ^{[1
]}

Caivano, R. ^{[1
]}

Metallo, V. ^{[1
]}

Chiumento, C. ^{[1
]}

Cozzolino, M. ^{[1
]}

Califano, G. ^{[1
]}

Clemente, S. ^{[1
]}

Pedicini, P. ^{[1
]}

Fusco, V. ^{[1
]}

机构：

[1] IRCCS CROB, Dept Radiat Oncol, I-85028 Rionero In Vulture, PZ, Italy

来源：

BRITISH JOURNAL OF RADIOLOGY | 2012年 / 85卷 / 1018期

关键词：

SUBMANDIBULAR-GLANDS; RADIATION-THERAPY; ANATOMIC CHANGES; IMRT; REGISTRATION; XEROSTOMIA; SHRINKAGE; CARCINOMA; SYSTEM; ORGANS;

D O I：

10.1259/bjr/30678306

中图分类号：

R8 [特种医学]; R445 [影像诊断学];

学科分类号：

1002 ; 100207 ; 1009 ;

摘要：

Objective: To evaluate volumetric changes of parotid glands (PGs) during intensity-modulated radiotherapy (IMRT) in head and neck cancer patients. Methods: During IMRT all patients underwent kilovolt cone-beam CT (CBCT) scans to verify the set-up positioning in a protocol study. On each CBCT scan, the PGs were retrospectively contoured and evaluated with a dose-volume histogram. Results: From February to June 2011, 10 patients were enrolled. 140 CBCT scans were registered (280 PGs): for each patient, a median of 14 CBCT scans were performed (range 14-16). At the start of radiation, the average volume for ipsilateral PGs (iPGs) was 18.77 ml (range 12.9-31.2 ml), whereas for contralateral PGs (cPGs) it was 16.63 ml (range 8.3-28.7 ml). At the last CBCT scan, the average volume loss was 43.5% and 44.0% for the iPG and cPG, respectively. When we analysed the percentage of volume loss, we observed that the volume decreased by linear regression (r(2)=0.92 for iPG; r(2)=0.91 for cPG), with an average volume loss rate of 1.5% per day for both PGs. During the third week of treatment the volume of both PGs reduced by 24-30%. Conclusion: Our data show that, during IMRT, the shrinkage of PGs should be taken into account. A replan could be indicated in the third week of radiotherapy.

引用

页码：1415 / 1419

页数：5