Cellular FLICE-like inhibitory proteins (c-FLIPs): Fine-tuners of life and death decisions

被引：91
|
作者：
Oeztuerk, Selcen [1 ]
Schleich, Kolja [1 ,2 ]
Lavrik, Inna N. [1 ,2 ,3 ,4 ]
机构：
[1] German Canc Res Ctr, Div Immunogenet, Heidelberg, Germany
[2] Bioquant, Heidelberg, Germany
[3] Otto Von Guericke Univ, Dept Translat Inflammat Res, Inst Expt Internal Med, Magdeburg, Germany
[4] German Canc Res Ctr, Div Theoret Bioinfornat, D-69120 Heidelberg, Germany
来源：
EXPERIMENTAL CELL RESEARCH | 2012年 / 318卷 / 11期
关键词：
c-FLIP; Death receptor; Apoptosis; Caspase-8; DISC; NF-KAPPA-B; RECEPTOR-INDUCED APOPTOSIS; SIGNALING COMPLEX; CD95-MEDIATED APOPTOSIS; CASPASE-8; ACTIVATION; T-CELLS; CFLIP ISOFORMS; UP-REGULATION; LONG FORM; FAS;
D O I：
10.1016/j.yexcr.2012.01.019
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
c-FLIP proteins (isoforms: c-FLIPL, c-FLIPs, and c-FLIPR) play an essential role in the regulation of death receptor (DR)-induced apoptosis and NF-kappa B activation. Here, we discuss multiple mechanisms by which c-FLIPs control NF-kappa B activation and the life/death decision made in cancer and immune cells. We focus on the role of c-FLIP in cellular signaling. We concentrate on c-FLIP protein modifications as well as on the regulation of c-FLIP expression levels. Furthermore, we discuss in detail how the exact quantity and dynamics of different c-FLIP isoforms in the cell influence the induction of pro- versus anti-apoptotic pathways. (C) 2012 Elsevier Inc. All rights reserved.
引用
收藏
页码：1324 / 1331
页数：8
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