Trichoderones A and B: Two Pentacyclic Cytochalasans from the Plant Endophytic Fungus Trichoderma gamsii

被引：40
|
作者：
Ding, Gang [2 ,3 ,4 ,5 ]
Wang, Hailou [2 ,3 ]
Li, Li [5 ]
Chen, Amanda Juan [2 ,3 ]
Chen, Lin [2 ,3 ]
Chen, Hong [6 ]
Zhang, Hongwu [2 ,3 ]
Liu, Xinzhong [1 ]
Zou, Zhongmei [2 ,3 ]
机构：
[1] Chinese Acad Sci, Key Lab Systemat Mycol & Lichenol, Inst Microbiol, Beijing 100080, Peoples R China
[2] Chinese Acad Med Sci, Key Lab Bioact Subst & Resources Utilizat Chinese, Minist Educ, Inst Med Plant Dev, Beijing 100193, Peoples R China
[3] Peking Union Med Coll, Beijing 100193, Peoples R China
[4] Chinese Acad Med Sci, Inst Mat Med, State Key Lab Bioact Substance & Funct Nat Med, Beijing 100050, Peoples R China
[5] Peking Union Med Coll, Beijing 100050, Peoples R China
[6] Med Coll Chinese Peoples Armed Police Force, Tianjin 300162, Peoples R China
来源：
EUROPEAN JOURNAL OF ORGANIC CHEMISTRY | 2012年 / 2012卷 / 13期
基金：
中国国家自然科学基金;
关键词：
Structure elucidation; Natural products; Cytotoxicity; Configuration determination; CONSTRUCTION;
D O I：
10.1002/ejoc.201200053
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
Two new cytochalasans, trichoderones A (1) and B (2), and three known analogues, aspochalasins D (3), J (4), and I (5), were isolated from the endophytic fungus Trichoderma gamsii. Their structures were determined by analysis of their spectroscopic data. The absolute configurations of 1 and 2 were established by quantum chemical electronic circular dichroism calculations. Compounds 3 and 4 displayed cytotoxic activity against the HeLa cell line. Trichoderone A (1) possesses an unprecedented 7/6/6/5/5 pentacyclic system, whereas trichoderone B (2) contains the rare 6/5/6/6/5 pentacyclic skeleton with a 12-oxatricyclo [6.3.1.02,7] moiety.
引用
收藏
页码：2516 / 2519
页数：4
相关论文
共 50 条
  • [41] Thiocytochalasins A-D, four sulfur-containing cytochalasans from an endophytic fungus Phoma multirostrata XJ-2-1
    Peng, Xiaogang
    Chang, Jinling
    Gao, Ying
    Duan, Fangfang
    Ruan, Hanli
    CHINESE CHEMICAL LETTERS, 2022, 33 (10) : 4572 - 4576
  • [42] Cytochalasans from the Endophytic Fungus Xylaria cf. curta with Resistance Reversal Activity against Fluconazole-Resistant Candida albicans
    Wang, Wen-Xuan
    Lei, Xinxiang
    Ai, Hong-Lian
    Bai, Xue
    Li, Jing
    He, Juan
    Li, Zheng-Hui
    Zheng, Yong-Sheng
    Feng, Tao
    Liu, Ji-Kai
    ORGANIC LETTERS, 2019, 21 (04) : 1108 - 1111
  • [43] Isolation of two peptaibols with potent antimicrobial and cytotoxic activities from the mangrove endophytic fungus Trichoderma lentiforme ML-P8-2
    Yin, Yihao
    Zhu, Ge
    Wu, Jianying
    She, Zhigang
    Yuan, Jie
    Wang, Bo
    NATURAL PRODUCT RESEARCH, 2024,
  • [44] Pestalotiones A-D: Four New Secondary Metabolites from the Plant Endophytic Fungus Pestalotiopsis Theae
    Guo, Longfang
    Lin, Jie
    Niu, Shubin
    Liu, Shuchun
    Liu, Ling
    MOLECULES, 2020, 25 (03):
  • [45] Phomoxins B and C:: Polyketides from an endophytic fungus of the genus Eupenicillium
    Davis, RA
    Andjic, V
    Kotiw, M
    Shivas, RG
    PHYTOCHEMISTRY, 2005, 66 (23) : 2771 - 2775
  • [46] Colletoindole A from the Mangrove Plant Endophytic Fungus Colletotrichum tropicale SCSIO 41022
    Lin, Xiuping
    Ai, Wen
    Li, Meng
    Pang, Xiaoyan
    Ju, Zhiran
    Guan, Da
    Yang, Bin
    Zhou, Xuefeng
    Wang, Junfeng
    Liu, Juan
    Wang, Lishu
    Liu, Yonghong
    CHEMISTRY & BIODIVERSITY, 2020, 17 (02)
  • [47] Pestaloficiols Q-S from the plant endophytic fungus Pestalotiopsis fici
    Liu, Shuchun
    Guo, Liangdong
    Che, Yongsheng
    Liu, Ling
    FITOTERAPIA, 2013, 85 : 114 - 118
  • [48] Fupyrones A and B, two new α-pyrones from an endophytic fungus, Fusarium sp. F20
    Gao, Han
    Li, Gang
    Peng, Xiao-Ping
    Lou, Hong-Xiang
    NATURAL PRODUCT RESEARCH, 2020, 34 (03) : 335 - 340
  • [49] Peniciriols A and B, two new citrinin derivatives from an endophytic fungus Penicillum citrinum TJNZ-27
    Wei, Shanshan
    Sang, Zihuan
    Zhang, Yanjiang
    Wang, Huan
    Chen, Yan
    Liu, Hongxin
    Wang, Sasa
    Tan, Haibo
    FITOTERAPIA, 2023, 169
  • [50] Pestalotiopamide E and pestalotiopin B from an endophytic fungus Aureobasidium pullulans isolated from Aloe vera leaves
    El-Amrani, Mustapha
    Ebada, Sherif S.
    Gad, Haidy A.
    Proksch, Peter
    PHYTOCHEMISTRY LETTERS, 2016, 18 : 95 - 98
12345