Trichoderones A and B: Two Pentacyclic Cytochalasans from the Plant Endophytic Fungus Trichoderma gamsii

被引：40
|
作者：
Ding, Gang [2 ,3 ,4 ,5 ]
Wang, Hailou [2 ,3 ]
Li, Li [5 ]
Chen, Amanda Juan [2 ,3 ]
Chen, Lin [2 ,3 ]
Chen, Hong [6 ]
Zhang, Hongwu [2 ,3 ]
Liu, Xinzhong [1 ]
Zou, Zhongmei [2 ,3 ]
机构：
[1] Chinese Acad Sci, Key Lab Systemat Mycol & Lichenol, Inst Microbiol, Beijing 100080, Peoples R China
[2] Chinese Acad Med Sci, Key Lab Bioact Subst & Resources Utilizat Chinese, Minist Educ, Inst Med Plant Dev, Beijing 100193, Peoples R China
[3] Peking Union Med Coll, Beijing 100193, Peoples R China
[4] Chinese Acad Med Sci, Inst Mat Med, State Key Lab Bioact Substance & Funct Nat Med, Beijing 100050, Peoples R China
[5] Peking Union Med Coll, Beijing 100050, Peoples R China
[6] Med Coll Chinese Peoples Armed Police Force, Tianjin 300162, Peoples R China
来源：
EUROPEAN JOURNAL OF ORGANIC CHEMISTRY | 2012年 / 2012卷 / 13期
基金：
中国国家自然科学基金;
关键词：
Structure elucidation; Natural products; Cytotoxicity; Configuration determination; CONSTRUCTION;
D O I：
10.1002/ejoc.201200053
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
Two new cytochalasans, trichoderones A (1) and B (2), and three known analogues, aspochalasins D (3), J (4), and I (5), were isolated from the endophytic fungus Trichoderma gamsii. Their structures were determined by analysis of their spectroscopic data. The absolute configurations of 1 and 2 were established by quantum chemical electronic circular dichroism calculations. Compounds 3 and 4 displayed cytotoxic activity against the HeLa cell line. Trichoderone A (1) possesses an unprecedented 7/6/6/5/5 pentacyclic system, whereas trichoderone B (2) contains the rare 6/5/6/6/5 pentacyclic skeleton with a 12-oxatricyclo [6.3.1.02,7] moiety.
引用
收藏
页码：2516 / 2519
页数：4
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