Trichoderones A and B: Two Pentacyclic Cytochalasans from the Plant Endophytic Fungus Trichoderma gamsii

被引：43

作者：

Ding, Gang ^{[2
,3
,4
,5
]}

Wang, Hailou ^{[2
,3
]}

Li, Li ^{[5
]}

Chen, Amanda Juan ^{[2
,3
]}

Chen, Lin ^{[2
,3
]}

Chen, Hong ^{[6
]}

Zhang, Hongwu ^{[2
,3
]}

Liu, Xinzhong ^{[1
]}

Zou, Zhongmei ^{[2
,3
]}

机构：

[1] Chinese Acad Sci, Key Lab Systemat Mycol & Lichenol, Inst Microbiol, Beijing 100080, Peoples R China

[2] Chinese Acad Med Sci, Key Lab Bioact Subst & Resources Utilizat Chinese, Minist Educ, Inst Med Plant Dev, Beijing 100193, Peoples R China

[3] Peking Union Med Coll, Beijing 100193, Peoples R China

[4] Chinese Acad Med Sci, Inst Mat Med, State Key Lab Bioact Substance & Funct Nat Med, Beijing 100050, Peoples R China

[5] Peking Union Med Coll, Beijing 100050, Peoples R China

[6] Med Coll Chinese Peoples Armed Police Force, Tianjin 300162, Peoples R China

来源：

EUROPEAN JOURNAL OF ORGANIC CHEMISTRY | 2012年 / 2012卷 / 13期

基金：

中国国家自然科学基金;

关键词：

Structure elucidation; Natural products; Cytotoxicity; Configuration determination; CONSTRUCTION;

D O I：

10.1002/ejoc.201200053

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Two new cytochalasans, trichoderones A (1) and B (2), and three known analogues, aspochalasins D (3), J (4), and I (5), were isolated from the endophytic fungus Trichoderma gamsii. Their structures were determined by analysis of their spectroscopic data. The absolute configurations of 1 and 2 were established by quantum chemical electronic circular dichroism calculations. Compounds 3 and 4 displayed cytotoxic activity against the HeLa cell line. Trichoderone A (1) possesses an unprecedented 7/6/6/5/5 pentacyclic system, whereas trichoderone B (2) contains the rare 6/5/6/6/5 pentacyclic skeleton with a 12-oxatricyclo [6.3.1.02,7] moiety.

引用

页码：2516 / 2519

页数：4

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