The involvement of lncRNAs in the development and progression of pancreatic cancer

被引：81
作者：
Li Duguang [1 ]
He Jin [2 ]
Qian Xiaowei [2 ]
Xu Peng [3 ]
Wang Xiaodong [3 ]
Li Zhennan [3 ]
Qian Jianjun [3 ]
Yao Jie [3 ]
机构：
[1] Dalian Med Univ, Clin Coll 2, 9 Western Dist,Lvshun South Rd, Dalian, Liaoning, Peoples R China
[2] Yangzhou Univ, Med Coll, Yangzhou, Jiangsu, Peoples R China
[3] Yangzhou Univ, Dept Hepatobiliary & Pancreat Surg, Northern Jiangsu Peoples Hosp, Clin Med Coll, Yangzhou 225001, Jiangsu, Peoples R China
来源：
CANCER BIOLOGY & THERAPY | 2017年 / 18卷 / 12期
关键词：
Cancer Stem Cells; Chemoresistance; EMT; Hypoxia; Long-non-coding RNAs (lncRNAs); Pancreatic cancer; Pancreatic Ductal Adenocarcinoma (PDAC); Tumor Microenvironment; LONG NONCODING RNA; EPITHELIAL-MESENCHYMAL TRANSITION; REGULATES CELL-PROLIFERATION; PREDICTS POOR-PROGNOSIS; UP-REGULATION; E-CADHERIN; HEPATOCELLULAR-CARCINOMA; GASTRIC-CANCER; TUMOR-GROWTH; STEM-CELLS;
D O I：
10.1080/15384047.2017.1385682
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
Pancreatic cancer is one of the most malignant tumors that are difficult to diagnose at its early stage and there is no effective therapy. Recent studies uncovered that many non-protein-coding RNAs including the class of long noncoding RNAs (lncRNAs) are differentially expressed in various types of tumors and they are potent regulators of tumor progression and metastasis. LncRNA can mediate tumor initiation, proliferation, migration and metastasis through modulating epigenetic modification, alternative splicing, transcription, and protein translation. In this review, we discuss the molecular mechanism of lncRNAs in the involvement of tumor growth, survival, epithelial-mesenchymal transition, tumor microenvironment, cancer stem cells and chemoresistance in pancreatic ductal adenocarcinoma (PDAC).
引用
收藏
页码：927 / 936
页数：10
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