The involvement of lncRNAs in the development and progression of pancreatic cancer

被引:81
作者
Li Duguang [1 ]
He Jin [2 ]
Qian Xiaowei [2 ]
Xu Peng [3 ]
Wang Xiaodong [3 ]
Li Zhennan [3 ]
Qian Jianjun [3 ]
Yao Jie [3 ]
机构
[1] Dalian Med Univ, Clin Coll 2, 9 Western Dist,Lvshun South Rd, Dalian, Liaoning, Peoples R China
[2] Yangzhou Univ, Med Coll, Yangzhou, Jiangsu, Peoples R China
[3] Yangzhou Univ, Dept Hepatobiliary & Pancreat Surg, Northern Jiangsu Peoples Hosp, Clin Med Coll, Yangzhou 225001, Jiangsu, Peoples R China
关键词
Cancer Stem Cells; Chemoresistance; EMT; Hypoxia; Long-non-coding RNAs (lncRNAs); Pancreatic cancer; Pancreatic Ductal Adenocarcinoma (PDAC); Tumor Microenvironment; LONG NONCODING RNA; EPITHELIAL-MESENCHYMAL TRANSITION; REGULATES CELL-PROLIFERATION; PREDICTS POOR-PROGNOSIS; UP-REGULATION; E-CADHERIN; HEPATOCELLULAR-CARCINOMA; GASTRIC-CANCER; TUMOR-GROWTH; STEM-CELLS;
D O I
10.1080/15384047.2017.1385682
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
Pancreatic cancer is one of the most malignant tumors that are difficult to diagnose at its early stage and there is no effective therapy. Recent studies uncovered that many non-protein-coding RNAs including the class of long noncoding RNAs (lncRNAs) are differentially expressed in various types of tumors and they are potent regulators of tumor progression and metastasis. LncRNA can mediate tumor initiation, proliferation, migration and metastasis through modulating epigenetic modification, alternative splicing, transcription, and protein translation. In this review, we discuss the molecular mechanism of lncRNAs in the involvement of tumor growth, survival, epithelial-mesenchymal transition, tumor microenvironment, cancer stem cells and chemoresistance in pancreatic ductal adenocarcinoma (PDAC).
引用
收藏
页码:927 / 936
页数:10
相关论文
共 119 条
  • [1] Dominant-negative histone H3 lysine 27 mutant derepresses silenced tumor suppressor genes and reverses the drug-resistant phenotype in cancer cells
    Abbosh, Phillip H.
    Montgomery, John S.
    Starkey, Jason A.
    Novotny, Milos
    Zuhowski, Eleanor G.
    Egorin, Merrill J.
    Moseman, Annie P.
    Golas, Adam
    Brannon, Kate M.
    Balch, Curtis
    Huang, Tim H. M.
    Nephew, Kenneth P.
    [J]. CANCER RESEARCH, 2006, 66 (11) : 5582 - 5591
  • [2] [Anonymous], ONCOTARGET
  • [3] Sonic Hedgehog Promotes Desmoplasia in Pancreatic Cancer
    Bailey, Jennifer M.
    Swanson, Benjamin J.
    Hamada, Tomofumi
    Eggers, John P.
    Singh, Pankaj K.
    Caffery, Thomas
    Ouellette, Michel M.
    Hollingsworth, Michael A.
    [J]. CLINICAL CANCER RESEARCH, 2008, 14 (19) : 5995 - 6004
  • [4] Identification and analysis of functional elements in 1% of the human genome by the ENCODE pilot project
    Birney, Ewan
    Stamatoyannopoulos, John A.
    Dutta, Anindya
    Guigo, Roderic
    Gingeras, Thomas R.
    Margulies, Elliott H.
    Weng, Zhiping
    Snyder, Michael
    Dermitzakis, Emmanouil T.
    Stamatoyannopoulos, John A.
    Thurman, Robert E.
    Kuehn, Michael S.
    Taylor, Christopher M.
    Neph, Shane
    Koch, Christoph M.
    Asthana, Saurabh
    Malhotra, Ankit
    Adzhubei, Ivan
    Greenbaum, Jason A.
    Andrews, Robert M.
    Flicek, Paul
    Boyle, Patrick J.
    Cao, Hua
    Carter, Nigel P.
    Clelland, Gayle K.
    Davis, Sean
    Day, Nathan
    Dhami, Pawandeep
    Dillon, Shane C.
    Dorschner, Michael O.
    Fiegler, Heike
    Giresi, Paul G.
    Goldy, Jeff
    Hawrylycz, Michael
    Haydock, Andrew
    Humbert, Richard
    James, Keith D.
    Johnson, Brett E.
    Johnson, Ericka M.
    Frum, Tristan T.
    Rosenzweig, Elizabeth R.
    Karnani, Neerja
    Lee, Kirsten
    Lefebvre, Gregory C.
    Navas, Patrick A.
    Neri, Fidencio
    Parker, Stephen C. J.
    Sabo, Peter J.
    Sandstrom, Richard
    Shafer, Anthony
    [J]. NATURE, 2007, 447 (7146) : 799 - 816
  • [5] Hypoxia, DNA repair and genetic instability
    Bristow, Robert G.
    Hill, Richard P.
    [J]. NATURE REVIEWS CANCER, 2008, 8 (03) : 180 - 192
  • [6] Examination of IGF2 and H19 loss of imprinting in bladder cancer
    Byun, Hyang-Min
    Wong, Hui-Lee
    Birnstein, Elliott Aaron
    Wolff, Erika M.
    Liang, Gangning
    Yang, Allen S.
    [J]. CANCER RESEARCH, 2007, 67 (22) : 10753 - 10758
  • [7] Epigenetic inhibition of miR-663b by long non-coding RNA HOTAIR promotes pancreatic cancer cell proliferation via up-regulation of insulin-like growth factor 2
    Cai, Huihua
    An, Yong
    Chen, Xuemin
    Sun, Donglin
    Chen, Tongbing
    Peng, Yan
    Zhu, Feng
    Jiang, Yong
    He, Xiaozhou
    [J]. ONCOTARGET, 2016, 7 (52) : 86857 - 86870
  • [8] Angiogenesis in cancer and other diseases
    Carmeliet, P
    Jain, RK
    [J]. NATURE, 2000, 407 (6801) : 249 - 257
  • [9] The oestrogen receptor alpha-regulated lncRNA NEAT1 is a critical modulator of prostate cancer
    Chakravarty, Dimple
    Sboner, Andrea
    Nair, Sujit S.
    Giannopoulou, Eugenia
    Li, Ruohan
    Hennig, Sven
    Mosquera, Juan Miguel
    Pauwels, Jonathan
    Park, Kyung
    Kossai, Myriam
    MacDonald, Theresa Y.
    Fontugne, Jacqueline
    Erho, Nicholas
    Vergara, Ismael A.
    Ghadessi, Mercedeh
    Davicioni, Elai
    Jenkins, Robert B.
    Palanisamy, Nallasivam
    Chen, Zhengming
    Nakagawa, Shinichi
    Hirose, Tetsuro
    Bander, Neil H.
    Beltran, Himisha
    Fox, Archa H.
    Elemento, Olivier
    Rubin, Mark A.
    [J]. NATURE COMMUNICATIONS, 2014, 5
  • [10] Progressive Upregulation of PD-1 in Primary and Metastatic Melanomas Associated with Blunted TCR Signaling in Infiltrating T Lymphocytes
    Chapon, Maxime
    Randriamampita, Clotilde
    Maubec, Eve
    Badoual, Cecile
    Fouquet, Stephane
    Wang, Shu-Fang
    Marinho, Eduardo
    Farhi, David
    Garcette, Marylene
    Jacobelli, Simon
    Rouquette, Alexandre
    Carlotti, Agnes
    Girod, Angelique
    Prevost-Blondel, Armelle
    Trautmann, Alain
    Avril, Marie-Francoise
    Bercovici, Nadege
    [J]. JOURNAL OF INVESTIGATIVE DERMATOLOGY, 2011, 131 (06) : 1300 - 1307