Water Soluble Polymers for Pharmaceutical Applications

被引:434
作者
Kadajji, Veeran Gowda [1 ]
Betageri, Guru V. [1 ]
机构
[1] Western Univ Hlth Sci, Dept Pharmaceut Sci, Pomona, CA 91766 USA
关键词
polymers; natural; synthetic; hydrogels; gums; cellulose ethers; povidone; polyethylene glycol; polyacrylamides; polyacrylic acid copolymers;
D O I
10.3390/polym3041972
中图分类号
O63 [高分子化学(高聚物)];
学科分类号
070305 ; 080501 ; 081704 ;
摘要
Advances in polymer science have led to the development of novel drug delivery systems. Some polymers are obtained from natural resources and then chemically modified for various applications, while others are chemically synthesized and used. A large number of natural and synthetic polymers are available. In the present paper, only water soluble polymers are described. They have been explained in two categories (1) synthetic and (2) natural. Drug polymer conjugates, block copolymers, hydrogels and other water soluble drug polymer complexes have also been explained. The general properties and applications of different water soluble polymers in the formulation of different dosage forms, novel delivery systems and biomedical applications will be discussed.
引用
收藏
页码:1972 / 2009
页数:38
相关论文
共 234 条
[51]   STRUCTURAL STUDIES OF GUM-ARABIC, THE EXUDATE POLYSACCHARIDE FROM ACACIA-SENEGAL [J].
DEFAYE, J ;
WONG, E .
CARBOHYDRATE RESEARCH, 1986, 150 (01) :221-231
[52]   Tissue reaction and biodegradation of implanted cross-linked high amylose starch in rats [J].
Desevaux, C ;
Dubreuil, P ;
Lenaerts, V ;
Girard, C .
JOURNAL OF BIOMEDICAL MATERIALS RESEARCH, 2002, 63 (06) :772-779
[53]   Cross-linked amylose as matrix for drug controlled release. X-ray and FT-IR structural analysis [J].
Dumoulin, Y ;
Alex, S ;
Szabo, P ;
Cartilier, L ;
Mateescu, MA .
CARBOHYDRATE POLYMERS, 1998, 37 (04) :361-370
[54]   Polymer-drug conjugates: towards a novel approach for the treatment of endrocine-related cancer [J].
Duncan, R ;
Vicent, MJ ;
Greco, F ;
Nicholson, RI .
ENDOCRINE-RELATED CANCER, 2005, 12 :S189-S199
[55]  
Eldon MA, 2007, AACR NCI EORTC INT C
[56]  
Evans W.C., 2002, TREASE EVANS PHARMAC, V15th ed., P206
[57]   GRAFT-POLYMERIZATION OF VINYL-ACETATE ONTO STARCH - SAPONIFICATION TO STARCH-G-POLY(VINYL ALCOHOL) [J].
FANTA, GF ;
BURR, RC ;
DOANE, WM ;
RUSSELL, CR .
JOURNAL OF APPLIED POLYMER SCIENCE, 1979, 23 (01) :229-240
[58]   Biocatalytic synthesis of highly ordered degradable dextran-based hydrogels [J].
Ferreira, L ;
Gil, MH ;
Cabrita, AMS ;
Dordick, JS .
BIOMATERIALS, 2005, 26 (23) :4707-4716
[59]   Characterization of glass solutions of poorly water-soluble drugs produced by melt extrusion with hydrophilic amorphous polymers [J].
Forster, A ;
Hempenstall, J ;
Rades, T .
JOURNAL OF PHARMACY AND PHARMACOLOGY, 2001, 53 (03) :303-315
[60]   Degradable dextran hydrogels: controlled release of a model protein from cylinders and microspheres [J].
Franssen, O ;
Vandervennet, L ;
Roders, P ;
Hennink, WE .
JOURNAL OF CONTROLLED RELEASE, 1999, 60 (2-3) :211-221