Sleep rebound attenuates context-dependent behavioural sensitization induced by amphetamine

被引:20
作者
Calzavara, Mariana Bendlin [2 ]
Andersen, Monica Levy [1 ]
Fukushiro, Daniela Fukue [2 ]
Lopez, Giorgia Batlle [2 ]
Abilio, Vanessa Costhek [2 ]
Tufik, Sergio [1 ]
Frussa-Filho, Roberto [2 ]
机构
[1] Univ Fed Sao Paulo, Dept Psychobiol, BR-04023062 Sao Paulo, Brazil
[2] Univ Fed Sao Paulo, Dept Pharmacol, BR-04023062 Sao Paulo, Brazil
基金
巴西圣保罗研究基金会;
关键词
amphetamine; context-dependent behavioural sensitization; conditioning; mice; paradoxical sleep deprivation; sleep rebound;
D O I
10.1016/j.pnpbp.2008.04.001
中图分类号
R74 [神经病学与精神病学];
学科分类号
摘要
We have recently demonstrated that paradoxical sleep deprivation (PSD) potentiates the induction of amphetamine (AMPH)-induced behavioural sensitization by increasing its conditioned component. In the present study, the effects of sleep rebound (induced by 24 h recovery period from PSD) were studied on AMPH-induced behavioural sensitization. Sleep rebound attenuated the acute locomotor-stimulating effect of AMPH. AMPH-induced behavioural sensitization was context-specific and was also attenuated by sleep rebound. These results strengthen the notion that sleep conditions can influence AMPH-incluced behavioural sensitization. (C) 2008 Elsevier Inc. All rights reserved.
引用
收藏
页码:1277 / 1282
页数:6
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