β-Cyclodextrin polymer nanoparticles as carriers for doxorubicin and artemisinin: a spectroscopic and photophysical study

被引：50
作者：
Anand, Resmi [1 ]
Manoli, Francesco [1 ]
Manet, Ilse [1 ]
Daoud-Mahammed, Samia [2 ]
Agostoni, Valentina [2 ]
Gref, Ruxandra [2 ]
Monti, Sandra [1 ]
机构：
[1] CNR, ISOF, I-40129 Bologna, Italy
[2] Univ Paris 11, CNRS, UMR 8612, F-92296 Chatenay Malabry, France
来源：
PHOTOCHEMICAL & PHOTOBIOLOGICAL SCIENCES | 2012年 / 11卷 / 08期
关键词：
IN-VITRO MODEL; INCLUSION COMPLEXATION; CIRCULAR-DICHROISM; GAMMA-CYCLODEXTRIN; ANTHRACYCLINE ANTIBIOTICS; EVAPORATIVE PRECIPITATION; ANTITUMOR-ACTIVITY; DAUNORUBICIN; DISSOLUTION; ENHANCEMENT;
D O I：
10.1039/c2pp25014d
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
The association of doxorubicin (DOX) and artemisinin (ART) to a beta-CyD-epichlorohydrin crosslinked polymer (p beta-CyD), organized in nanoparticles of ca. 15 nm size, was investigated in neutral aqueous medium by circular dichroism (CD), UV-vis absorption and fluorescence. The stability constants and the absolute CD spectra of the drug complexes were determined by global analysis of multiwavelength data from spectroscopic titrations. The polymer p beta-CyD proved able to disrupt the DOX dimer when the latter is the predominant form of DOX in solution. The spectroscopic and photophysical properties of the complexes evidenced an alcohol-like environment for ART and an improved inherent emission ability for DOX in the nanoparticle frame.
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收藏
页码：1285 / 1292
页数：8
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