Antifungal activity of ionic liquids based on (-)-menthol: a mechanism study

被引：61
作者：
Suchodolski, Jakub [1 ]
Feder-Kubis, Joanna [2 ]
Krasowska, Anna [1 ]
机构：
[1] Univ Wroclaw, Fac Biotechnol, Joilot Curie 14a, PL-50383 Wroclaw, Poland
[2] Wroclaw Univ Sci & Technol, Fac Chem, Wybrzeze Wyspianskiego 27, PL-50370 Wroclaw, Poland
来源：
MICROBIOLOGICAL RESEARCH | 2017年 / 197卷
关键词：
Ionic liquids; Antifungal activity; Candida albicans; Membrane permeabilisation; Cell wall destruction; CANDIDA-ALBICANS; ALKYLTRIBUTYLPHOSPHONIUM CHLORIDES; ESCHERICHIA-COLI; PSEUDOFACTIN II; ADHESION; MENTHOL; SURFACTANTS; INFECTIONS; HEMOLYSIS; TOXICITY;
D O I：
10.1016/j.micres.2016.12.008
中图分类号：
Q93 [微生物学];
学科分类号：
071005 ; 100705 ;
摘要：
The mechanism of toxicity of chiral ionic liquids with (1R,2S,5R)-(-)-menthol [C-n-Am-Men][Cl] (n = 10, 11 or 12) in the fungus Candida albicans is reported here. Ionic liquids were more toxic towards Candida strain lacking all identified multidrug resistance efflux pumps. Moreover, the compounds tested inhibited C. albicans filamentation at the concentration at which detached fungal cells also adhered to the plastic surface. Our results showed the high activity of all the tested chiral ionic liquids in the permeabilization of C albicans' membranes and in the digestion and interruption of the cell wall. The investigated ionic liquids thus have potential as disinfectants because besides their antifungal and antiadhesive action these compounds do not cause hemolysis. (C) 2017 Elsevier GmbH. All rights reserved.
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收藏
页码：56 / 64
页数：9
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