Risk factors for medullary thyroid carcinoma: a pooled analysis

被引:28
作者
Negri, E
Ron, E
Franceschi, S
La Vecchia, C
Preston-Martin, S
Kolonel, L
Kleinerman, RA
Mabuchi, K
Jin, F
Wingren, G
Hallquist, A
Levi, F
Linos, A
Fraumeni, JF
机构
[1] Mario Negri Inst Pharmacol Res, I-20157 Milan, Italy
[2] NCI, Bethesda, MD 20892 USA
[3] Int Agcy Res Canc, Field & Intervent Studies Unit, F-69372 Lyon, France
[4] Univ Milan, Ist Stat Med & Biometria, I-20122 Milan, Italy
[5] Univ So Calif, Dept Prevent Med, Los Angeles, CA 90089 USA
[6] Univ Hawaii Manoa, Canc Res Ctr Hawaii, Honolulu, HI 96822 USA
[7] Radiat Effects Res Fdn, Hiroshima 732, Japan
[8] Shanghai Canc Inst, Shanghai, Peoples R China
[9] Linkoping Univ, Dept Hlth & Environm, Div Environm & Occupat Med, Linkoping, Sweden
[10] Karolinska Inst, Dept Oncol Pathol, Stockholm, Sweden
[11] CHU Vaudois, Inst Univ Med Sociale & Prevent, Registre Vaudois Tumeurs, CH-1011 Lausanne, Switzerland
[12] Athens Med Sch, Dept Epidemiol, Athens, Greece
关键词
case-control studies; epidemiology; medullary thyroid carcinoma; risk;
D O I
10.1023/A:1015263718760
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
Objective: To investigate risk factors for medullary thyroid cancer (MTC). Methods: We conducted a pooled analysis of 14 case-control studies from Europe, North America, and Asia, including 67 medullary cancers (43 women and 24 men) diagnosed in ten studies. Of the original 4776, we selected five controls per case matched on study, gender, and age. The pooled odds ratios (OR) were estimated using conditional logistic regression. Results: Education, weight, and body mass were not associated with MTC, but a significant positive relationship was seen with height (OR = 2.6 for highest vs lowest tertile). Significant excess risks were associated with a history of thyroid nodules (OR = 12), hypertension (OR = 2.3), gallbladder disease (OR = 4.3), and allergies (OR = 2.2). Among current smokers, a decreased risk of MTC was observed with increasing number of cigarettes. The risk was significantly elevated among women having a first birth after age 25 years, but no clear pattern emerged for other reproductive factors. Conclusions: Although the number of MTC was small, we detected several significant associations, including prior thyroid and other diseases.
引用
收藏
页码:365 / 372
页数:8
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