PKM2 and ACVR 1C are prognostic markers for poor prognosis of gallbladder cancer

被引：44
作者：
Li, J. [1 ,4 ]
Yang, Z. [2 ]
Zou, Q. [3 ]
Yuan, Y. [3 ]
Li, J. [1 ,4 ]
Liang, L. [5 ]
Zeng, G. [6 ]
Chen, S. [7 ]
机构：
[1] Cent S Univ, Dept Surg, Changsha 410011, Hunan, Peoples R China
[2] Cent S Univ, Xiangya Hosp 2, Res Lab Hepatobiliary Dis, Changsha 410011, Hunan, Peoples R China
[3] Cent S Univ, Xiangya Hosp 3, Dept Pathol, Changsha 410011, Hunan, Peoples R China
[4] Cent S Univ, Xiangya Med Sch, Dept Pathol, Changsha 410011, Hunan, Peoples R China
[5] Hunan Prov Peoples Hosp, Dept Hepatobiliary & Pancreat Surg, Changsha 410007, Hunan, Peoples R China
[6] Loudi Cent Hosp, Dept Pathol, Loudi 417011, Hunan, Peoples R China
[7] Hunan Prov Tumor Hosp, Dept Pathol, Changsha 410013, Hunan, Peoples R China
来源：
CLINICAL & TRANSLATIONAL ONCOLOGY | 2014年 / 16卷 / 02期
关键词：
Gallbladder cancer; PKM2; ACVR; 1C; Prognosis; KINASE TYPE M2; TUMOR; GROWTH; CELL; PROGRESSION; CARCINOMA;
D O I：
10.1007/s12094-013-1063-8
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
To identify biological markers related to the progression and prognosis of GBC. The expressions of pyruvate kinase isoenzyme type M2 (PKM2) and activin A receptor type IC (ACVR 1C) in 46 squamous cell/adenosquamous carcinomas (SC/ASC) and 80 adenocarcinomas (AC) were examined using immunohistochemistry. Positive PKM2 and negative ACVR 1C expressions were significantly associated with lymph node metastasis, invasion and TNM stage of SC/ASCs and ACs. Univariate Kaplan-Meier analysis showed that either elevated PKM2 or loss of ACVR 1C expression significantly correlated with shorter average survival times in both SC/ASC and AC patients. Multivariate Cox regression analysis showed that positive PKM2 expression and loss of ACVR 1C expression were poor prognosis biomarkers in both SC/ASC and AC patients. Our study suggested that PKM2 overexpression is a marker of metastasis, invasion and poor prognosis of GBC. ACVR 1C is a tumor suppressor, and lowered ACVR 1C expression is an important marker for the metastasis, invasion, and prognosis of GBC.
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收藏
页码：200 / 207
页数：8
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