Effects of intermittent fasting on body composition and clinical health markers in humans

被引:254
作者
Tinsley, Grant M. [1 ]
La Bounty, Paul M. [2 ]
机构
[1] Baylor Univ, Dept Hlth Human Performance & Recreat, Waco, TX 76798 USA
[2] Univ Mary Hardin Baylor, Dept Exercise & Sport Sci, Belton, TX USA
关键词
alternate-day fasting; body composition; intermittent fasting; meal frequency; weight loss; whole-day fasting; LDL PARTICLE-SIZE; LOW-CALORIE DIETS; WEIGHT-LOSS; MEAL FREQUENCY; INSULIN SENSITIVITY; ENERGY RESTRICTION; GLUCOSE-METABOLISM; CARDIO-PROTECTION; FEEDING FREQUENCY; GLYCEMIC CONTROL;
D O I
10.1093/nutrit/nuv041
中图分类号
R15 [营养卫生、食品卫生]; TS201 [基础科学];
学科分类号
100403 ;
摘要
Intermittent fasting is a broad term that encompasses a variety of programs that manipulate the timing of eating occasions by utilizing short-term fasts in order to improve body composition and overall health. This review examines studies conducted on intermittent fasting programs to determine if they are effective at improving body composition and clinical health markers associated with disease. Intermittent fasting protocols can be grouped into alternate-day fasting, whole-day fasting, and time-restricted feeding. Alternate-day fasting trials of 3 to 12 weeks in duration appear to be effective at reducing body weight (approximate to 3%-7%), body fat (approximate to 3-5.5 kg), total cholesterol (approximate to 10%-21%), and triglycerides (approximate to 14%-42%) in normal-weight, overweight, and obese humans. Whole-day fasting trials lasting 12 to 24 weeks also reduce body weight (approximate to 3%-9%) and body fat, and favorably improve blood lipids (approximate to 5%-20% reduction in total cholesterol and approximate to 17%-50% reduction in triglycerides). Research on time-restricted feeding is limited, and clear conclusions cannot be made at present. Future studies should examine long-term effects of intermittent fasting and the potential synergistic effects of combining intermittent fasting with exercise.
引用
收藏
页码:661 / 674
页数:14
相关论文
共 81 条
[1]   The effect of total starvation and very low energy diet in lean men on kinetics of whole body protein and five hepatic secretory proteins [J].
Afolabi, Paul R. ;
Jahoor, Farook ;
Jackson, Alan A. ;
Stubbs, James ;
Johnstone, Alexander M. ;
Faber, Peter ;
Lobley, Gerald ;
Gibney, Eileen ;
Elia, Marinos .
AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM, 2007, 293 (06) :E1580-E1589
[2]   Maintenance following a very-low-calorie diet [J].
Agras, WS ;
Berkowitz, RI ;
Arnow, BA ;
Telch, CF ;
Marnell, M ;
Henderson, J ;
Morris, Y ;
Wilfley, DE .
JOURNAL OF CONSULTING AND CLINICAL PSYCHOLOGY, 1996, 64 (03) :610-613
[3]   The skinny on fat: lipolysis and fatty acid utilization in adipocytes [J].
Ahmadian, Maryam ;
Duncan, Robin E. ;
Sul, Hei Sook .
TRENDS IN ENDOCRINOLOGY AND METABOLISM, 2009, 20 (09) :424-428
[4]  
Aoki T T, 1981, Prog Clin Biol Res, V67, P161
[5]   Effect of intensive dietetic interventions on weight and glycaemic control in overweight men with Type II diabetes: a randomised trial [J].
Ash, S ;
Reeves, MM ;
Yeo, S ;
Morrison, G ;
Carey, D ;
Capra, S .
INTERNATIONAL JOURNAL OF OBESITY, 2003, 27 (07) :797-802
[6]  
Benedict FG., 1915, STUDY PROLONGED FAST
[7]   Alternate Day Fasting and Endurance Exercise Combine to Reduce Body Weight and Favorably Alter Plasma Lipids in Obese Humans [J].
Bhutani, Surabhi ;
Klempel, Monica C. ;
Kroeger, Cynthia M. ;
Trepanowski, John F. ;
Varady, Krista A. .
OBESITY, 2013, 21 (07) :1370-1379
[8]   Improvements in Coronary Heart Disease Risk Indicators by Alternate-Day Fasting Involve Adipose Tissue Modulations [J].
Bhutani, Surabhi ;
Klempel, Monica C. ;
Berger, Reed A. ;
Varady, Krista A. .
OBESITY, 2010, 18 (11) :2152-2159
[9]  
Blomain Erik Scott, 2013, ISRN Obes, V2013, P210524, DOI 10.1155/2013/210524
[10]   Effects of the Dietary Approaches to Stop Hypertension Diet Alone and in Combination With Exercise and Caloric Restriction on Insulin Sensitivity and Lipids [J].
Blumenthal, James A. ;
Babyak, Michael A. ;
Sherwood, Andrew ;
Craighead, Linda ;
Lin, Pao-Hwa ;
Johnson, Julie ;
Watkins, Lana L. ;
Wang, Jenny T. ;
Kuhn, Cynthia ;
Feinglos, Mark ;
Hinderliter, Alan .
HYPERTENSION, 2010, 55 (05) :1199-1205