Phosphoinositide 3-kinase and INPP4B in human breast cancer

被引：38

作者：

Bertucci, Micka C. ^{[1
]}

Mitchell, Christina A. ^{[1
]}

机构：

[1] Monash Univ, Dept Biochem & Mol Biol, Clayton, Vic 3800, Australia

来源：

INOSITOL PHOSPHOLIPID SIGNALING IN PHYSIOLOGY AND DISEASE | 2013年 / 1280卷

基金：

英国医学研究理事会;

关键词：

PI3K; breast cancer; PTEN; 4-phosphatase; INPP4B; TUMOR-SUPPRESSOR; PATHWAY; PIK3CA; EXPRESSION; MUTATIONS; PTEN;

D O I：

10.1111/nyas.12036

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

The PI3K/Akt signaling pathway is frequently increased in many human cancers, including breast cancer. Recent studies have identified INPP4B, which inhibits PI3K signaling, as an emerging tumor suppressor in breast cancer. This short review discusses these issues and the possibility that INPP4B is an important regulator in many cancers.

引用

页码：1 / 5

页数：5

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