Prognostic factors of 112 elderly patients with advanced non-small cell lung cancer

被引:4
作者
Ran, Fanglan [1 ]
Liu, Qjn [1 ]
机构
[1] Chongqing Univ, Dept Resp & Crit Care Med, Fuling Hosp, 2 Gaosuntang Rd, Chongqing 408000, Peoples R China
关键词
Advanced; Non-small cell lung cancer; Prognostic factors; Median survival time; Retrospective analysis; PERFORMANCE STATUS; EXPRESSION; SURVIVAL;
D O I
10.12669/pjms.38.6.5457
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Objectives: In this study we retrospectively analyzed the prognostic factors of patients with advanced non-small cell lung cancer (NSCLC). Methods: Clinical data of 112 patients with advanced NSCLC treated in the tumor center of our hospital from January 2016 to December 2017 were analyzed retrospectively, follow up the survival of patients, the effects of gender, age, tumor stage, pathological type, performance status (PS) score, smoking history and treatment on the survival of elderly patients with advanced NSCLC were analyzed. Results: The median survival time was 12.0 months, and the median age was 74 years. The 3-year survival rate after confirmation of advanced lung cancer was 6.25%. Kaplan Meier univariate analysis showed that age, PS score, smoking status and treatment correlated with the prognosis(P<0.05). Cox multivariate analysis showed that age >70 years, PS score>2, smoking and no targeted therapy were independent adverse prognostic factors for elderly patients with advanced NSCLC(P<0.05). Conclusions: Age, PS score, smoking and treatment mode affect the prognosis and survival of elderly patients with advanced NSCLC. Effective treatment should be given according to the principle of evidence-based medicine.
引用
收藏
页码:1674 / 1679
页数:6
相关论文
共 21 条
  • [1] Systemic Therapy for Locally Advanced and Metastatic Non-Small Cell Lung Cancer A Review
    Arbour, Kathryn C.
    Riely, Gregory J.
    [J]. JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION, 2019, 322 (08): : 764 - 774
  • [2] Bacha Saoussen, 2017, Tunis Med, V95, P772
  • [3] Clinical observation of docetaxel or gemcitabine combined with cisplatin in the chemotherapy after surgery for stage II-III non-small cell lung cancer
    Chen, Qiu-Qiang
    Ji, Xue-Xian
    Zhou, Xiao
    Shi, Qi-Lin
    Yu, Huan-Ming
    Fu, Heng-Qin
    Ji, Guo-Ping
    [J]. WSPOLCZESNA ONKOLOGIA-CONTEMPORARY ONCOLOGY, 2015, 19 (04): : 323 - 326
  • [4] Prognostic value of survivin expression in stage III non-small cell lung cancer patients treated with platinum-based therapy
    Cho, Hyun Jin
    Kim, Hyeong Ryul
    Park, Young Soo
    Kim, Yong-Hee
    Kim, Dong Kwan
    Park, Seung-Il
    [J]. SURGICAL ONCOLOGY-OXFORD, 2015, 24 (04): : 329 - 334
  • [5] Cancer statistics for adults aged 85 years and older, 2019
    DeSantis, Carol E.
    Miller, Kimberly D.
    Dale, William
    Mohile, Supriya G.
    Cohen, Harvey J.
    Leach, Corinne R.
    Sauer, Ann Goding
    Lemal, Ahmedin
    Siegel, Rebecca L.
    [J]. CA-A CANCER JOURNAL FOR CLINICIANS, 2019, 69 (06) : 452 - 467
  • [6] Non-Small Cell Lung Cancer: Epidemiology, Screening, Diagnosis, and Treatment
    Duma, Narjust
    Santana-Davila, Rafael
    Molina, Julian R.
    [J]. MAYO CLINIC PROCEEDINGS, 2019, 94 (08) : 1623 - 1640
  • [7] Poor-Performance Status Assessment of Patients with Non-small Cell Lung Cancer Remains Vague and Blurred in the Immunotherapy Era
    Friedlaender, Alex
    Banna, Giuseppe Luigi
    Buffoni, Lucio
    Addeo, Alfredo
    [J]. CURRENT ONCOLOGY REPORTS, 2019, 21 (12)
  • [8] Correlation between expression of epidermal growth factor receptor and adverse reactions after chemotherapy of advanced non-small-cell lung cancer
    Hao, Zerui
    Tian, Chunyan
    Yang, Futang
    Zhang, Jihong
    [J]. PAKISTAN JOURNAL OF MEDICAL SCIENCES, 2015, 31 (05) : 1115 - 1120
  • [9] Palliative chemotherapy and targeted therapies for esophageal and gastroesophageal junction cancer
    Janmaat, Vincent T.
    Steyerberg, Ewout W.
    van der Gaast, Ate
    Mathijssen, Ron H. J.
    Bruno, Marco J.
    Peppelenbosch, Maikel P.
    Kuipers, Ernst J.
    Spaander, Manon C. W.
    [J]. COCHRANE DATABASE OF SYSTEMATIC REVIEWS, 2017, (11):
  • [10] Performance Status and Smoking Status Are Independent Favorable Prognostic Factors for Survival in Non-small Cell Lung Cancer A Comprehensive Analysis of 26,957 Patients with NSCLC
    Kawaguchi, Tomoya
    Takada, Minoru
    Kubo, Akihito
    Matsumura, Akihide
    Fukai, Shimao
    Tamura, Atsuhisa
    Saito, Ryusei
    Maruyama, Yosihito
    Kawahara, Masaaki
    Ignatius, Sai-Hong
    [J]. JOURNAL OF THORACIC ONCOLOGY, 2010, 5 (05) : 620 - 630