Fundamental Interactions in RNA: Questions Answered and Remaining

被引：12
作者：
Turner, Douglas H. [1 ,2 ]
机构：
[1] Univ Rochester, Dept Chem, Rochester, NY 14627 USA
[2] Univ Rochester, Ctr RNA Biol, Rochester, NY 14627 USA
来源：
BIOPOLYMERS | 2013年 / 99卷 / 12期
关键词：
thermodynamics; RNA; stacking; hydrogen bonding; molecular dynamics; NEAREST-NEIGHBOR MODEL; SELF-COMPLEMENTARY OLIGORIBONUCLEOTIDES; FREE-ENERGY CHANGES; SECONDARY STRUCTURE; INTERNAL LOOPS; THERMODYNAMIC STABILITIES; 2-DIMENSIONAL NMR; BASE-PAIRS; ELECTROSTATIC PROPERTIES; CHEMICAL-MODIFICATION;
D O I：
10.1002/bip.22294
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Interpreting the tsunami of sequence information for RNA would be facilitated by an understanding of all the physical principles determining RNA structure. In principle, a complete understanding would make it computationally possible to find RNA sequences that fold for function and to predict their three-dimensional structure. It would, thus, also facilitate discovery of new principles relating structure to function. This review covers some of the progress in understanding RNA over roughly the preceding 40 years and suggests progress still to be made. (c) 2013 Wiley Periodicals, Inc. Biopolymers 99: 1097-1104, 2013.
引用
收藏
页码：1097 / 1104
页数：8
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