Effects of 5-HT7 receptors on circadian rhythm of mice anesthetized with isoflurane

被引：4
作者：
Liu, Binwen [1 ]
Chu, Shuaishuai [1 ]
Liu, Tiantian [1 ]
Song, Jia [1 ]
Ma, Zhengliang [1 ]
Gu, Xiaoping [1 ]
Xia, Tianjiao [1 ,2 ]
机构：
[1] Nanjing Univ, Sch Med, Affiliated Hosp, Dept Anesthesiol,Nanjing Drum Tower Hosp, 321 Zhong Shan Rd, Nanjing 210008, Jiangsu, Peoples R China
[2] Nanjing Univ, Jiangsu Key Lab Mol Med, Nanjing 210093, Peoples R China
来源：
CHRONOBIOLOGY INTERNATIONAL | 2021年 / 38卷 / 01期
关键词：
Anesthesia; circadian rhythm; serotonin; 7; receptor; phase shift; suprachiasmatic nucleus; mouse model; LOCOMOTOR-ACTIVITY; BODY-TEMPERATURE; AGONISTS; SLEEP;
D O I：
10.1080/07420528.2020.1832111
中图分类号：
Q [生物科学];
学科分类号：
07 ; 0710 ; 09 ;
摘要：
The role of the serotonin 7 receptor (5-HT(7)receptor) subtype in a number of domains has been widely recognized, but its role in the regulation of changes of the circadian rhythm after anesthesia is still unclear. We used intraperitoneal injection of 5-HT(7)receptor agonist LP-211 or antagonist SB-269970 in mice to influence the level of 5-HT(7)receptor protein in the SCN and to observe the role of this receptor on circadian rhythm changes after isoflurane anesthesia. Our results show the appropriate dose of SB-269970 significantly alleviated the circadian rhythm disorder induced by isoflurane anesthesia, while LP-211 significantly aggravated it after anesthesia, which is different from the phase shift that can be caused by the administration of LP-211 before anesthesia. These findings may indicate the 5-HT(7)receptor plays a complex role in the regulation of circadian rhythm after anesthesia. Our findings may provide some positive significance for alleviating circadian rhythm disorder in patients after anesthesia and ultimately promoting rapid postoperative recovery.
引用
收藏
页码：38 / 45
页数：8
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