Abnormal Corpus Callosum Integrity in Bipolar Disorder: A Diffusion Tensor Imaging Study

被引：115

作者：

Wang, Fei ^{[1
,5
]}

Kalmar, Jessica H. ^{[1
,5
]}

Edmiston, Elliot Kale ^{[1
,5
]}

Chepenik, Lara G. ^{[1
,5
]}

Bhagwagar, Zubin ^{[1
]}

Spencer, Linda ^{[1
,5
]}

Pittman, Brian ^{[1
]}

Jackowski, Marcel ^{[2
,6
]}

Papaclemetris, Xenophon ^{[2
,3
]}

Constable, R. Todd ^{[2
,3
,4
]}

Blumberg, Hilary P. ^{[1
,2
,5
]}

机构：

[1] Yale Univ, Sch Med, Dept Psychiat, 333 Cedar St,Suite 901, New Haven, CT 06511 USA

[2] Yale Univ, Sch Med, Dept Diagnost Radiol, New Haven, CT 06511 USA

[3] Yale Univ, Sch Med, Dept Biomed Engn, New Haven, CT 06511 USA

[4] Yale Univ, Sch Med, Dept Neurosurg, New Haven, CT 06511 USA

[5] VA CT Healthcare Syst, Dept Psychiat, West Haven, CT USA

[6] Univ Sao Paulo, Inst Math & Stat, BR-05508 Sao Paulo, Brazil

来源：

BIOLOGICAL PSYCHIATRY | 2008年 / 64卷 / 08期

关键词：

Bipolar disorder; corpus callosum; diffusion tensor imaging; fractional anisotropy;

D O I：

10.1016/j.biopsych.2008.06.001

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Objective: Abnormalities in the anterior interhemispheric connections provided by the corpus callosum (CC) have long been implicated in bipolar disorder (BID). In this study, we used complementary diffusion tensor imaging methods to study the structural integrity of the CC and localization of potential abnormalities in BD. Methods: Subjects included 33 participants with BID and 40 healthy comparison participants. Fractional anisotropy (FA) measures were compared between groups with region of interest (ROD methods to investigate the anterior, middle, and posterior CC and voxel-based methods to further localize abnormalities. Results: In ROI-based analyses, FA was significantly decreased in the anterior and middle CC in the BID group (p <.05). Voxel-based analyses similarly localized group differences to the genu, rostral body, and anterior midbody of CC (p <.05, corrected). Conclusion: The findings demonstrate abnormalities in the structural integrity of the anterior CC in BID that might contribute to altered interhemispheric connectivity in this disorder.

引用

页码：730 / 733

页数：4

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