Tumor-associated macrophages in lung cancer: Friend or foe?

被引：62

作者：

Xu, Fei ^{[1
,2
]}

Wei, Ying ^{[2
]}

Tang, Zhao ^{[2
]}

Liu, Baojun ^{[2
]}

Dong, Jingcheng ^{[2
]}

机构：

[1] Shandong Univ Tradit Chinese Med, Dept Geriatr Med, Affiliated Hosp, Jinan 250014, Shandong, Peoples R China

[2] Fudan Univ, Dept Integrat Med, Huashan Hosp, 12 Middle Urumqi Rd, Shanghai 200032, Peoples R China

来源：

MOLECULAR MEDICINE REPORTS | 2020年 / 22卷 / 05期

关键词：

tumor-associated macrophages; lung cancer; tumor microenvironment; targeted therapy; STIMULATING FACTOR-I; M2; MACROPHAGES; INFILTRATING MACROPHAGES; ALVEOLAR MACROPHAGES; CELL-MIGRATION; UP-REGULATION; POOR-PROGNOSIS; TGF-BETA; EXPRESSION; POLARIZATION;

D O I：

10.3892/mmr.2020.11518

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Typically, tumor-associated macrophages (TAMs), an abundant population of leukocytes in lung cancer, are affected by tumor microenvironment (TME) and shift towards either a pro-tumor (M2-like) or an anti-tumor phenotype (M1-like). M2-polarized macrophages, are one of the primary tumor-infiltrating immune cells and were reported to be associated with the promotion of cancer cell growth, invasion, metastasis, and angiogenesis. TAMs are considered a potential target for adjuvant anticancer therapies, and recent therapeutic approaches targeting the M2 polarization of TAMs have shown encouraging results. The present review discusses recent developments in the role of TAMs in cancer, in particular TAMs functions, clinical implication and prospective therapeutic strategies in lung cancer.

引用

页码：4107 / 4115

页数：9

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