INCREASED KYNURENINE/TRYPTOPHAN AND NEOPTERIN LEVELS IN HEMODIALYSIS

被引：0
作者：
Hacisevki, A. [1 ]
Baba, B. [1 ]
Sezer, S. [2 ]
Ozkan, Y. [1 ]
机构：
[1] Gazi Univ, Fac Pharm, Dept Biochem, TR-06330 Ankara, Turkey
[2] Baskent Univ, Fac Med, Dept Nephrol, TR-06490 Ankara, Turkey
来源：
OXIDATION COMMUNICATIONS | 2013年 / 36卷 / 01期
关键词：
hemodialysis; kynurenine; kynurenine/tryptophan; neopterin; tryptophan; CHRONIC-RENAL-FAILURE; TRYPTOPHAN-METABOLISM; KYNURENINE PATHWAY; DISEASE; DEGRADATION; INFLAMMATION;
D O I：
暂无
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
In our study, the tryptophan degradation via the kynurenine pathway and neopterin levels as markers of cellular immune activity were evaluated in hemodialysis (HD) patients in order to confirm the data of previous studies. In this case-control study, serum tryptophan and kynurenine concentrations were determined by HPLC, neopterin levels were measured with ELISA in 54 hemodialysis patients and 33 healthy controls. There were significantly increased kynurenine, kynurenine/tryptophan ratio and neopterin levels, and decreased tryptophan levels in hemodialysis patients compared with the healthy controls (p=0.0001). In our study, tryptophan degradation and neopterin levels are increased in HD patients. These changes may result from impaired excretion of the compounds or neopterin production and tryptophan degradation in the course of inflammation and immune activation during hemodialysis.
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页码：246 / 253
页数：8
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