+P5(D1S3309E), a novel target binding site for the Wilms' tumour suppressor 1 (WT1) gene, maps to human chromosome 1q21->q22

被引：6

作者：

Negus, K ^{[1
]}

Holmes, GH ^{[1
]}

Wicking, C ^{[1
]}

Wainwright, BJ ^{[1
]}

Little, MH ^{[1
]}

机构：

[1] UNIV QUEENSLAND, CTR CELLULAR & MOLEC BIOL, ST LUCIA, QLD 4072, AUSTRALIA

来源：

CYTOGENETICS AND CELL GENETICS | 1996年 / 72卷 / 04期

关键词：

D O I：

10.1159/000134210

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

The Wilms' tumour suppressor 1 gene (WT1) encodes a zinc finger transcription factor critical for normal urogenital development. We have previously isolated a DNA fragment, +P5 (D1S3309E), to which all WT 1 protein isoforms bind. Using PCR of a human x rodent somatic cell hybrid mapping panel, together with two-color fluorescence in situ hybridisation of +P5-containing cosmids and previously localised human chromosome 1q cosmids, we have mapped the +P5 fragment to chromosome 1q21-->q22.

引用

页码：306 / 309

页数：4

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