+P5(D1S3309E), a novel target binding site for the Wilms' tumour suppressor 1 (WT1) gene, maps to human chromosome 1q21->q22

被引：6

作者：

Negus, K ^{[1
]}

Holmes, GH ^{[1
]}

Wicking, C ^{[1
]}

Wainwright, BJ ^{[1
]}

Little, MH ^{[1
]}

机构：

[1] UNIV QUEENSLAND, CTR CELLULAR & MOLEC BIOL, ST LUCIA, QLD 4072, AUSTRALIA

来源：

CYTOGENETICS AND CELL GENETICS | 1996年 / 72卷 / 04期

关键词：

D O I：

10.1159/000134210

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

The Wilms' tumour suppressor 1 gene (WT1) encodes a zinc finger transcription factor critical for normal urogenital development. We have previously isolated a DNA fragment, +P5 (D1S3309E), to which all WT 1 protein isoforms bind. Using PCR of a human x rodent somatic cell hybrid mapping panel, together with two-color fluorescence in situ hybridisation of +P5-containing cosmids and previously localised human chromosome 1q cosmids, we have mapped the +P5 fragment to chromosome 1q21-->q22.

引用

页码：306 / 309

页数：4

共 24 条

[1] MODULATION OF DNA-BINDING SPECIFICITY BY ALTERNATIVE SPLICING OF THE WILMS-TUMOR WT1 GENE TRANSCRIPT [J].

BICKMORE, WA ;

OGHENE, K ;

LITTLE, MH ;

SEAWRIGHT, A ;

VANHEYNINGEN, V ;

HASTIE, ND .

SCIENCE, 1992, 257 (5067) :235-237

[2] ISOLATION AND CHARACTERIZATION OF A ZINC FINGER POLYPEPTIDE GENE AT THE HUMAN CHROMOSOME-11 WILMS TUMOR LOCUS [J].

CALL, KM ;

GLASER, T ;

ITO, CY ;

BUCKLER, AJ ;

PELLETIER, J ;

HABER, DA ;

ROSE, EA ;

KRAL, A ;

YEGER, H ;

LEWIS, WH ;

JONES, C ;

HOUSMAN, DE .

CELL, 1990, 60 (03) :509-520

[3]

CHOO KH, 1986, GENE, V46, P277, DOI 10.1016/0378-1119(86)90412-9

[4] THE ROLE OF WT1 IN WILMS TUMORIGENESIS [J].

COPPES, MJ ;

CAMPBELL, CE ;

WILLIAMS, BRG .

FASEB JOURNAL, 1993, 7 (10) :886-895

[5] HOMOZYGOUS DELETION IN WILMS-TUMORS OF A ZINC-FINGER GENE IDENTIFIED BY CHROMOSOME JUMPING [J].

GESSLER, M ;

POUSTKA, A ;

CAVENEE, W ;

NEVE, RL ;

ORKIN, SH ;

BRUNS, GAP .

NATURE, 1990, 343 (6260) :774-778

[6] FAMILIAL PREDISPOSITION TO WILMS TUMOR DOES NOT MAP TO THE SHORT ARM OF CHROMOSOME-11 [J].

GRUNDY, P ;

KOUFOS, A ;

MORGAN, K ;

LI, FP ;

MEADOWS, AT ;

CAVENEE, WK .

NATURE, 1988, 336 (6197) :374-376

[7] AN INTERNAL DELETION WITHIN AN 11P13 ZINC FINGER GENE CONTRIBUTES TO THE DEVELOPMENT OF WILMS-TUMOR [J].

HABER, DA ;

BUCKLER, AJ ;

GLASER, T ;

CALL, KM ;

PELLETIER, J ;

SOHN, RL ;

DOUGLASS, EC ;

HOUSMAN, DE .

CELL, 1990, 61 (07) :1257-1269

[8] ALTERNATIVE SPLICING AND GENOMIC STRUCTURE OF THE WILMS-TUMOR GENE-WT1 [J].

HABER, DA ;

SOHN, RL ;

BUCKLER, AJ ;

PELLETIER, J ;

CALL, KM ;

HOUSMAN, DE .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1991, 88 (21) :9618-9622

[9]

HUFF V, 1992, CANCER RES, V52, P6117

[10] LACK OF LINKAGE OF FAMILIAL WILMS TUMOR TO CHROMOSOMAL BAND 11P13 [J].

HUFF, V ;

COMPTON, DA ;

CHAO, LY ;

STRONG, LC ;

GEISER, CF ;

SAUNDERS, GF .

NATURE, 1988, 336 (6197) :377-378

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