Preparation of chitin nanogels containing nickel nanoparticles

被引：25

作者：

Kumar, N. Ashwin ^{[1
]}

Rejinold, N. Sanoj ^{[1
]}

Anjali, P. ^{[1
]}

Balakrishnan, Avinash ^{[1
]}

Biswas, Raja ^{[1
]}

Jayakumar, R. ^{[1
]}

机构：

[1] Amrita Vishwa Vidyapeetham Univ, Amrita Inst Med Sci & Res Ctr, Amrita Ctr Nanosci & Mol Med, Cochin 682041, Kerala, India

来源：

CARBOHYDRATE POLYMERS | 2013年 / 97卷 / 02期

关键词：

Nickel nanoparticles; Chitin nanogels; Cytocompatibility; Antibacterial activity; Biomedical applications; OXIDE NANOPARTICLES; POLYMER NANOGELS; CROSS-LINKING;

D O I：

10.1016/j.carbpol.2013.05.009

中图分类号：

O69 [应用化学];

学科分类号：

081704 ;

摘要：

In this work, we developed 120-150 nm sized nickel nanoparticles loaded chitin nanogels (Ni-Chitin NGs) by regeneration chemistry approach to investigate and determine its cytocompatibility and antibacterial activity against Staphylococcus aureus. The nickel nanoparticles were prepared by hydrothermal method. The prepared Ni-Chitin NGs were well characterized by SEM, FTIR, TG/DTA/DTG and XRD and the in vitro cytocompatibility was tested on A549 and L929 cells which showed that they are completely non-toxic. Ni-Chitin NGs showed better toxicity to the bacterial strains when compared to previous study with other nanoparticles using serial dilution method. The rhodamine labeled-Ni-Chitin NGs showed cellular localization on both L929 and A549 cells without perturbing their cellular constituents. These studies showed that the Ni-Chitin NGs could be used for various applications in biomedical filed. (C) 2013 Elsevier Ltd. All rights reserved.

引用

页码：469 / 474

页数：6

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