Protein-bound polysaccharide decreases invasiveness and proliferation in pancreatic cancer by inhibition of hedgehog signaling and HIF-1α pathways under hypoxia

被引：29
|
作者：
Onishi, Hideya [1 ]
Morisaki, Takafumi [1 ]
Nakao, Fumihiko [1 ]
Odate, Seiichi [1 ]
Morisaki, Takashi [2 ]
Katano, Mitsuo [1 ]
机构：
[1] Kyushu Univ, Grad Sch Med Sci, Dept Canc Therapy & Res, Fukuoka 8128582, Japan
[2] Fukuoka Gen Canc Clin, Fukuoka, Japan
来源：
CANCER LETTERS | 2013年 / 335卷 / 02期
关键词：
PSK; Hedgehog signaling; HIF-1; alpha; Pancreatic cancer; Hypoxia; PSK INDUCES APOPTOSIS; INDUCIBLE FACTOR; IMMUNOMODULATOR; 5-FLUOROURACIL; DOCETAXEL; INVASION; IMMUNITY; KINASE; TARGET; GROWTH;
D O I：
10.1016/j.canlet.2013.02.041
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
To develop an effective therapeutic approach to pancreatic ductal adenocarcinoma (PDAC), we focused on the antitumor mechanism of protein-bound polysaccharide (PSK) under hypoxia. PSK decreased proliferation in PDAC cells under hypoxia but not normoxia. PSK also showed anti-tumor effects in vivo, inhibited invasiveness of PDAC cells, and decreased the expression of HIF-1 alpha and hedgehog (Hh) signaling-related molecules under hypoxia. Inhibition of HIF-1 alpha and Hh signaling reduced proliferation and invasiveness in PDAC cells under hypoxia. In conclusion, we found new PSK-related pathways in invasiveness and proliferation in PDAC under hypoxia. PSK may be a promising therapeutic drug to treat refractory PDAC. (c) 2013 Elsevier Ireland Ltd. All rights reserved.
引用
收藏
页码：289 / 298
页数：10
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