Microbubble-Mediated Intravascular Ultrasound Imaging and Drug Delivery

被引：14

作者：

Dixon, Adam J. ^{[1
]}

Kilroy, Joseph P. ^{[1
]}

Dhanaliwala, Ali H. ^{[1
]}

Chen, Johnny L. ^{[1
]}

Phillips, Linsey C. ^{[2
]}

Ragosta, Michael ^{[3
]}

Klibanov, Alexander L. ^{[3
]}

Wamhoff, Brian R. ^{[3
]}

Hossack, John A. ^{[1
]}

机构：

[1] Univ Virginia, Dept Biomed Engn, Charlottesville, VA 22908 USA

[2] Stanford Univ, Dept Radiol, Palo Alto, CA 94304 USA

[3] Univ Virginia, Div Cardiovasc, Sch Med, Charlottesville, VA 22908 USA

来源：

IEEE TRANSACTIONS ON ULTRASONICS FERROELECTRICS AND FREQUENCY CONTROL | 2015年 / 62卷 / 09期

关键词：

ACOUSTIC RADIATION FORCE; CORONARY-ARTERY-DISEASE; CONTRAST AGENTS; VASA VASORUM; ATHEROSCLEROTIC PLAQUE; MYOCARDIAL-PERFUSION; INTRACORONARY ULTRASOUND; MECHANICAL-PROPERTIES; CLINICAL-OUTCOMES; ELUTING STENTS;

D O I：

10.1109/TUFFC.2015.007143

中图分类号：

O42 [声学];

学科分类号：

070206 ; 082403 ;

摘要：

Intravascular ultrasound (IVUS) provides radiation-free, real-time imaging and assessment of atherosclerotic disease in terms of anatomical, functional, and molecular composition. The primary clinical applications of IVUS imaging include assessment of luminal plaque volume and real-time image guidance for stent placement. When paired with micro-bubble contrast agents, IVUS technology may be extended to provide nonlinear imaging, molecular imaging, and therapeutic delivery modes. In this review, we discuss the development of emerging imaging and therapeutic applications that are enabled by the combination of IVUS imaging technology and micro-bubble contrast agents.

引用

页码：1674 / 1685

页数：12

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