Flavonoid intake and risk of pancreatic cancer in the National Institutes of Health-AARP Diet and Health Study Cohort

被引：12
作者：
Arem, H. [1 ,2 ]
Bobe, G. [3 ]
Sampson, J. [2 ]
Subar, A. F. [4 ]
Park, Y. [2 ]
Risch, H. [1 ,5 ]
Hollenbeck, A. [6 ]
Mayne, S. T. [1 ,5 ]
Stolzenberg-Solomon, R. Z. [2 ]
机构：
[1] Yale Univ, Sch Publ Hlth, New Haven, CT 06520 USA
[2] NCI, Div Canc Epidemiol & Genet, Bethesda, MD 20892 USA
[3] Univ Oregon, Linus Pauling Inst, Corvallis, OR USA
[4] NCI, Div Canc Control & Populat Sci, Bethesda, MD 20892 USA
[5] Yale Canc Ctr, New Haven, CT USA
[6] AARP, Washington, DC USA
来源：
BRITISH JOURNAL OF CANCER | 2013年 / 108卷 / 05期
基金：
美国国家卫生研究院;
关键词：
pancreatic neoplasms; flavonoids; epidemiology; cohort studies; RETIRED-PERSONS DIET; AMERICAN-ASSOCIATION; POLYPHENOLS;
D O I：
10.1038/bjc.2012.584
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
Background: Limited epidemiological studies show inverse associations between dietary flavonoid intake and pancreatic cancer risk, but results are inconsistent and are based on few cases. We examined the association between intake of flavonoids and pancreatic cancer risk in the large, prospective National Institutes of Health-AARP Diet and Health Study Cohort. Methods: During follow-up through 2006 (median follow-up 10.6 years), 2379 pancreatic cancer cases were identified. We used Cox proportional hazards modelling to estimate hazard ratios (HRs) and 95% confidence intervals (CIs). Results: We found no association between total flavonoid intake (Q5 vs Q1 HR = 1.09, 95% CI: 0.96-1.24) or any flavonoid subtypes and pancreatic cancer risk. Significant interactions were not observed by age, sex, smoking status, BMI or diabetes. Conclusion: Our results do not support the hypothesis that flavonoids have a protective role in pancreatic cancer carcinogenesis.
引用
收藏
页码：1168 / 1172
页数：5
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