Synthesis of novel N-sulfonyl monocyclic β-lactams as potential antibacterial agents

被引：62

作者：

Jarrahpour, A ^{[1
]}

Zarei, M ^{[1
]}

机构：

[1] Shiraz Univ, Coll Sci, Dept Chem, Shiraz 71454, Iran

来源：

MOLECULES | 2006年 / 11卷 / 01期

关键词：

2-azetidinones; N-sulfonyl beta-lactams; ketene; imine; CAN; DMAP;

D O I：

10.3390/11010049

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

New cis monocyclic beta-lactams were synthesized by [2+2] Staudinger cycloaddition reactions of the imine (3,4-dimethoxybenzylldc:ne)-(4-methoxyphenyl)amine and ketenes derived from different acyl chlorides and Et3N. These monocyclic beta-lactams were then cleaved by ceric ammonium nitrate (CAN) to give NH-monocyclic beta-lactams, which in turn were converted to N-sulfonyl monocyclic beta-lactams by treatment with four different sulfonyl chlorides in the presence of Et3N and 4,4-dimethylaminopyridine (DMAP).

引用

页码：49 / 58

页数：10

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