A one-pot synthesis of polysubstituted imidazol[1,2-a]pyridines

被引：19

作者：

Kiselyov, AS ^{[1
]}

机构：

[1] Chem Divers, Small Mol Drug Discovery, San Diego, CA 92121 USA

来源：

TETRAHEDRON LETTERS | 2006年 / 47卷 / 17期

关键词：

one-pot reactions; imidazo[1,2-a]pyridines; alpha; beta-unsaturated imines; condensations;

D O I：

10.1016/j.tetlet.2006.02.115

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A series of 5,7,8-polysubstituted imidazo[1,2-a]pyridines were synthesized regioselectively from in situ generated alpha,beta-unsaturated imines and dianions derived from methyl azolyl acetates in a one-pot procedure. The targeted molecules were conveniently isolated in analytically pure form (ca. 50-70% yields) by trituration of the concentrated reaction mixtures with cold ether. (c) 2006 Elsevier Ltd. All rights reserved.

引用

页码：2941 / 2944

页数：4

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