Organocatalyzed Asymmetric Synthesis of Dihydrodibenzofurans Based on a Dienamine Process

被引：30

作者：

Wang, Zi-Yu ^{[1
]}

Wong, Wing-Tak ^{[1
]}

Yang, Dan ^{[1
]}

机构：

[1] Univ Hong Kong, Dept Chem, Hong Kong, Hong Kong, Peoples R China

来源：

ORGANIC LETTERS | 2013年 / 15卷 / 19期

关键词：

DIELS-ALDER REACTION; ALPHA; BETA-UNSATURATED ALDEHYDES; OXIDATIVE CYCLIZATION; 2-ALLYLPHENOLS; OXYPALLADATION; CYCLOADDITION; ANNULATION; CATALYSIS;

D O I：

10.1021/ol402288y

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The first organocatalyzed asymmetric method for the synthesis of dihydrodibenzofurans based on a dienamine process has been developed. This two-step protocol works with a broad range of substrates and delivers only the cis-diastereomer in good yield with up to 91% ee. The enantioenriched products have been transformed to highly functionalized and partially hydrogenated dibenzofurans in excellent diastereoselectivities.

引用

页码：4980 / 4983

页数：4

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