Challenges and Key Considerations of the Enhanced Permeability and Retention Effect for Nanomedicine Drug Delivery in Oncology

被引：1180

作者：

Prabhakar, Uma ^{[1
]}

Maeda, Hiroshi ^{[2
]}

Jain, Rakesh K. ^{[3
,4
]}

Sevick-Muraca, Eva M. ^{[7
]}

Zamboni, William ^{[8
]}

Farokhzad, Omid C. ^{[5
,6
]}

Barry, Simon T. ^{[9
]}

Gabizon, Alberto ^{[10
,11
]}

Grodzinski, Piotr ^{[1
]}

Blakey, David C. ^{[9
]}

机构：

[1] NCI, Alliance Nanotechnol Canc, Bethesda, MD 20892 USA

[2] Sojo Univ, Inst DDS Res, Kumamoto, Japan

[3] Harvard Univ, Sch Med, Cambridge, MA 02138 USA

[4] Massachusetts Gen Hosp, Boston, MA 02114 USA

[5] Harvard Univ, Sch Med, Boston, MA USA

[6] Brigham & Womens Hosp, Boston, MA 02115 USA

[7] Univ Texas Hlth Sci Ctr, Brown Fdn Inst Mol Med, Houston, TX USA

[8] Univ N Carolina, UNC Lineberger Comprehens Canc Ctr, UNC Eshelman Sch Pharm, Chapel Hill, NC USA

[9] AstraZeneca, Macclesfield, Cheshire, England

[10] Shaare Zedek Med Ctr, Jerusalem, Israel

[11] Hebrew Univ Jerusalem, Sch Med, IL-91010 Jerusalem, Israel

来源：

CANCER RESEARCH | 2013年 / 73卷 / 08期

关键词：

MACROMOLECULAR THERAPEUTICS; SOLID TUMORS;

D O I：

10.1158/0008-5472.CAN-12-4561

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Enhanced permeability of the tumor vasculature allows macromolecules to enter the tumor interstitial space, whereas the suppressed lymphatic filtration allows them to stay there. This phenomenon, enhanced permeability and retention (EPR), has been the basis of nanotechnology platforms to deliver drugs to tumors. However, progress in developing effective drugs using this approach has been hampered by heterogeneity of EPR effect in different tumors and limited experimental data from patients on effectiveness of this mechanism as related to enhanced drug accumulation. This report summarizes the workshop discussions on key issues of the EPR effect and major gaps that need to be addressed to effectively advance nanoparticle-based drug delivery. Cancer Res; 73(8); 2412-7. (C) 2013 AACR.

引用

页码：2412 / 2417

页数：6

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