Prognostic role of p21WAF1 expression in areca quid chewing and smoking-associated oral squamous cell carcinoma in Taiwan

被引:8
作者
Kuo, MYP [1 ]
Huang, JS [1 ]
Kok, SH [1 ]
Kuo, YS [1 ]
Chiang, CP [1 ]
机构
[1] Natl Taiwan Univ Hosp, Sch Dent, Taipei 100, Taiwan
关键词
areca quid chewing; oral squamous cell carcinoma; p21(WAF1); p53;
D O I
10.1046/j.0904-2512.2001.10055.x
中图分类号
R78 [口腔科学];
学科分类号
1003 ;
摘要
Background: Alterations in p21(WAF1) protein expression have been observed in a wide variety of human cancers by immunohistochemistry, and both decreased and increased levels of p21(WAF1) protein expression have been shown to correlate with poor prognosis. Method: To examine the relation between p21(WAF1) protein expression and prognosis in oral squamous cell carcinomas (SCCs), we performed an immunohistochemical study with antip21(WAF1) antibody on 43 oral SCCs. Immunostaining results were then correlated with p53 protein levels, clinicopathological parameters of the tumors and overall patient survival. Results: Of the 43 patients, 31 (72%) had tumors with positive p21(WAF1) nuclear staining and 27 (63%) had tumors with p53 nuclear staining. There was no significant correlation between p21(WAF1) and p53 protein expressions and both mutant p53-containing oral SCCs overexpressed p21(WAF1) protein. In addition, no significant correlation was found between the p21(WAF1) expression and the patients' age, sex, oral habit, cancer location, or primary tumor TNM status at the time of initial presentation. The Kaplan-Meier analysis showed a significant correlation between p21(WAF1) protein overexpression and poor patient overall survival (P=0.049). When p53 and p21(WAF1) were evaluated together, the 5-year overall survival was lowest in p53(+)-p21(WAF1)(+) patients and highest in p53(-)-p21(WAF1) (-) patients (P=0.057). Conclusion: Combined evaluation of p21(WAF1) and p53 expressions may be useful in estimating the prognosis of patients with oral SCCs in Taiwan.
引用
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页码:16 / 22
页数:7
相关论文
共 51 条
  • [1] Aaltomaa S, 1999, PROSTATE, V39, P8
  • [2] Expression of cyclin dependent kinase inhibitor p21waf1/cip1 in premalignant and malignant oral lesions:: relationship with p53 status
    Agarwal, S
    Mathur, M
    Shukla, NK
    Ralhan, R
    [J]. ORAL ONCOLOGY, 1998, 34 (05): : 353 - 360
  • [3] p21/WAF1 expression as related to p53, cell proliferation and prognosis in epithelial ovarian cancer
    Anttila, MA
    Kosma, VM
    Hongxiu, J
    Puolakka, J
    Juhola, M
    Saarikoski, S
    Syrjänen, K
    [J]. BRITISH JOURNAL OF CANCER, 1999, 79 (11-12) : 1870 - 1878
  • [4] BENNETT WP, 1991, ONCOGENE, V6, P1779
  • [5] HIGH PREVALENCE OF HUMAN PAPILLOMAVIRUS INFECTION AND POSSIBLE ASSOCIATION WITH BETEL QUID CHEWING AND SMOKING IN ORAL EPIDERMOID CARCINOMAS IN TAIWAN
    CHANG, KW
    CHANG, CS
    LAI, KS
    CHOU, MJ
    CHOO, KB
    [J]. JOURNAL OF MEDICAL VIROLOGY, 1989, 28 (01) : 57 - 61
  • [6] CHEN YQ, 1995, CANCER RES, V55, P4536
  • [7] Chiang CP, 1999, J ORAL PATHOL MED, V28, P72
  • [8] Cox LS, 1997, J PATHOL, V183, P134, DOI 10.1002/(SICI)1096-9896(199710)183:2<134::AID-PATH960>3.0.CO
  • [9] 2-D
  • [10] TUMOR SUPPRESSORS, KINASES AND CLAMPS - HOW P53 REGULATES THE CELL-CYCLE IN RESPONSE TO DNA-DAMAGE
    COX, LS
    LANE, DP
    [J]. BIOESSAYS, 1995, 17 (06) : 501 - 508