Antioxidant Effects and Cytoprotective Potentials of Herbal Tea against H2O2-Induced Oxidative Damage by Activating Heme Oxygenase1 Pathway

被引:6
作者
Zhang, Ke-Xin [1 ,2 ]
Tan, Jian-Bin [1 ]
Xie, Cheng-Liang [3 ]
Zheng, Rong-Bo [4 ]
Huang, Xiao-Dan [4 ]
Zhang, Meng-Meng [1 ]
Zhao, Min [1 ]
机构
[1] Ctr Dis Control & Prevent Guangdong Prov, Guangzhou 511430, Peoples R China
[2] Sun Yat Sen Univ, Dept Med Stat & Epidemiol, Guangdong Prov Key Lab Food Nutr & Hlth, Guangdong Engn Technol Res Ctr Nutr Translat,Sch, Guangzhou 510000, Peoples R China
[3] Sun Yat Sen Univ, Sch Pharmaceut Sci Shenzhen, Guangzhou 510000, Peoples R China
[4] Guangzhou Wanlaoji Pharmaceut Co Ltd, Guangzhou 510403, Peoples R China
关键词
STRESS; EXPRESSION; BILIRUBIN; HEALTH; GROWTH; CELLS;
D O I
10.1155/2020/7187946
中图分类号
Q81 [生物工程学(生物技术)]; Q93 [微生物学];
学科分类号
071005 ; 0836 ; 090102 ; 100705 ;
摘要
Herbal tea with antioxidant ingredients has gained increasing attention in the field of functional foods due to their amelioration potential in aging-related diseases. Wanglaoji herbal tea (WHT) is a kind of traditional beverage made from herbal materials. This study was performed to investigate its antioxidant activity and identify its protective effect on a H2O2-induced cell damage model. In this study, we identified six kinds of phenolic acids with antioxidant activity in WHT, among which rosmarinic acid had the highest content and the highest contribution ratio to the antioxidant activity of WHT. Moreover, compared with the H2O2-induced damage group, the WHT treatment group can significantly increase the viability of cells and decrease the ratio of senescence-associated beta-galactosidase-positive cells, intracellular malondialdehyde levels, and the percentage of G1 phase. Furthermore, enrichment analysis of differentially expressed genes revealed that heme oxygenase1 (HMOX1) was a key gene for protective effect of WHT on oxidative stress-induced cell damage. Thus, WHT exerted protective effects not only by scavenging reactive oxygen species but also by inducing the expression of cytoprotective genes by activating the HMOX1 pathway, which showed that WHT had a potential of promoting health by reducing oxidative stress-induced cell damage.
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页数:10
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