On the biosynthesis of an inhibitor of the p53/MDM2 interaction

被引：15
作者：
Duncan, SJ
Williams, DH
Ainsworth, M
Martin, S
Ford, R
Wrigley, SK
机构：
[1] Univ Cambridge, Cambridge Ctr Mol Recognit, Chem Lab, Cambridge CB2 1EW, England
[2] Cubist Pharmaceut UK Ltd, Slough SL1 4EQ, Berks, England
来源：
TETRAHEDRON LETTERS | 2002年 / 43卷 / 06期
基金：
英国医学研究理事会;
关键词：
D O I：
10.1016/S0040-4039(01)02239-0
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
The biosynthesis of a fungal secondary metabolite, chlorofusin, which disrupts the interaction between the proteins p53 and MDM2, has been investigated; the acetogenic origin of the chromophore backbone as well as of an aminodecanoic acid residue is demonstrated. (C) 2002 Elsevier Science Ltd. All rights reserved.
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页码：1075 / 1078
页数：4
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