AGO unchained: Canonical and non-canonical roles of Argonaute proteins in mammals

被引：14
|
作者：
Sala, Laura [1 ]
Chandrasekhar, Srividya [1 ]
Vidigal, Joana A. [1 ]
机构：
[1] NCI, Lab Biochem & Mol Biol, Bethesda, MD 20892 USA
来源：
FRONTIERS IN BIOSCIENCE-LANDMARK | 2020年 / 25卷
基金：
美国国家卫生研究院;
关键词：
microRNAs; endo-siRNAs; Argonaute; mammals; In Vivo; Review; MEDIATED TRANSLATIONAL REPRESSION; DOUBLE-STRANDED-RNA; TARGETED MESSENGER-RNAS; EMBRYONIC STEM-CELLS; ENDOGENOUS SIRNAS; CRYSTAL-STRUCTURE; GENE-EXPRESSION; DISTINCT ROLES; GUIDE RNA; MICRORNA MATURATION;
D O I：
10.2741/4793
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Argonaute (AGO) proteins play key roles in animal physiology by binding to small RNAs and regulating the expression of their targets. In mammals, they do so through two distinct pathways: the miRNA pathway represses genes through a multiprotein complex that promotes both decay and translational repression; the siRNA pathway represses transcripts through direct Ago2-mediated cleavage. Here, we review our current knowledge of mechanistic details and physiological requirements of both these pathways and briefly discuss their implications to human disease.
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页码：1 / 42
页数：42
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