AGO unchained: Canonical and non-canonical roles of Argonaute proteins in mammals

被引：14
|
作者：
Sala, Laura [1 ]
Chandrasekhar, Srividya [1 ]
Vidigal, Joana A. [1 ]
机构：
[1] NCI, Lab Biochem & Mol Biol, Bethesda, MD 20892 USA
来源：
FRONTIERS IN BIOSCIENCE-LANDMARK | 2020年 / 25卷
基金：
美国国家卫生研究院;
关键词：
microRNAs; endo-siRNAs; Argonaute; mammals; In Vivo; Review; MEDIATED TRANSLATIONAL REPRESSION; DOUBLE-STRANDED-RNA; TARGETED MESSENGER-RNAS; EMBRYONIC STEM-CELLS; ENDOGENOUS SIRNAS; CRYSTAL-STRUCTURE; GENE-EXPRESSION; DISTINCT ROLES; GUIDE RNA; MICRORNA MATURATION;
D O I：
10.2741/4793
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Argonaute (AGO) proteins play key roles in animal physiology by binding to small RNAs and regulating the expression of their targets. In mammals, they do so through two distinct pathways: the miRNA pathway represses genes through a multiprotein complex that promotes both decay and translational repression; the siRNA pathway represses transcripts through direct Ago2-mediated cleavage. Here, we review our current knowledge of mechanistic details and physiological requirements of both these pathways and briefly discuss their implications to human disease.
引用
收藏
页码：1 / 42
页数：42
相关论文
共 50 条
  • [1] Non-canonical roles of canonical telomere binding proteins in cancers
    Akincilar, Semih Can
    Chan, Claire Hian Tzer
    Ng, Qin Feng
    Fidan, Kerem
    Tergaonkar, Vinay
    CELLULAR AND MOLECULAR LIFE SCIENCES, 2021, 78 (09) : 4235 - 4257
  • [2] Non-canonical roles of canonical telomere binding proteins in cancers
    Semih Can Akincilar
    Claire Hian Tzer Chan
    Qin Feng Ng
    Kerem Fidan
    Vinay Tergaonkar
    Cellular and Molecular Life Sciences, 2021, 78 : 4235 - 4257
  • [3] Canonical and non-canonical roles of complement in atherosclerosis
    Maffia, Pasquale
    Mauro, Claudio
    Case, Ayden
    Kemper, Claudia
    NATURE REVIEWS CARDIOLOGY, 2024, 21 (11) : 743 - 761
  • [4] Canonical and non-canonical roles for ATG8 proteins in autophagy and beyond
    Reid, Steven Edward
    Kolapalli, Srinivasa Prasad
    Nielsen, Thorbjorn M.
    Frankel, Lisa B. B.
    FRONTIERS IN MOLECULAR BIOSCIENCES, 2022, 9
  • [5] Non-canonical roles of autophagy proteins in endocytosis and exocytosis
    Munz, Christian
    BIOCHEMICAL SOCIETY TRANSACTIONS, 2021, 49 (06) : 2841 - 2851
  • [6] Non-canonical roles of connexins
    Van Campenhout, Raf
    Cooreman, Axelle
    Leroy, Kaat
    Rusiecka, Olga M.
    Van Brantegem, Pieter
    Annaert, Pieter
    Muyldermans, Serge
    Devoogdt, Nick
    Cogliati, Bruno
    Kwak, Brenda R.
    Vinken, Mathieu
    PROGRESS IN BIOPHYSICS & MOLECULAR BIOLOGY, 2020, 153 : 35 - 41
  • [7] Canonical and Non-Canonical Roles of Human DNA Polymerase η
    Bedaiwi, Salma
    Usmani, Anam
    Carty, Michael P.
    GENES, 2024, 15 (10)
  • [8] Non-Canonical Roles of Dengue Virus Non-Structural Proteins
    Zeidler, Julianna D.
    Fernandes-Siqueira, Lorena O.
    Barbosa, Glauce M.
    Da Poian, Andrea T.
    VIRUSES-BASEL, 2017, 9 (03):
  • [9] Canonical and Non-Canonical Roles of GRK2 in Lymphocytes
    Cheng, Jing
    Lucas, Peter C.
    McAllister-Lucas, Linda M.
    CELLS, 2021, 10 (02) : 1 - 13
  • [10] Canonical and Non-Canonical Roles of Connexin43 in Cardioprotection
    Rusiecka, Olga M.
    Montgomery, Jade
    Morel, Sandrine
    Batista-Almeida, Daniela
    Van Campenhout, Raf
    Vinken, Mathieu
    Girao, Henrique
    Kwak, Brenda R.
    BIOMOLECULES, 2020, 10 (09) : 1 - 22
12345