CGRP in human models of primary headaches

被引：25
作者：
Ashina, Hakan [1 ]
Schytz, Henrik Winther [1 ]
Ashina, Messoud [1 ]
机构：
[1] Univ Copenhagen, Fac Hlth & Med Sci, Rigshosp Glostrup, Danish Headache Ctr,Dept Neurol, Nordre Ringvej 57, DK-2600 Glostrup, Denmark
来源：
CEPHALALGIA | 2018年 / 38卷 / 02期
关键词：
CGRP; human provocation models; primary headaches; migraine; GENE-RELATED PEPTIDE; FAMILIAL HEMIPLEGIC MIGRAINE; CYCLASE-ACTIVATING POLYPEPTIDE-38; TRIGEMINAL NUCLEUS CAUDALIS; DOUBLE-BLIND; TRIGEMINOVASCULAR SYSTEM; NERVE-FIBERS; SUBSTANCE-P; EXTRACEREBRAL CIRCULATION; RECEPTOR ANTAGONIST;
D O I：
10.1177/0333102416684344
中图分类号：
R74 [神经病学与精神病学];
学科分类号：
摘要：
Objective To review the role of CGRP in human models of primary headaches and to discuss methodological aspects and future directions. Discussion Provocation experiments demonstrated a heterogeneous CGRP migraine response in migraine patients. Conflicting CGRP plasma results in the provocation experiments are likely due to assay variation; therefore, proper validation and standardization of an assay is needed. To what extent CGRP is involved in tension-type headache and cluster headache is unknown. Conclusion Human models of primary headaches have elucidated the role of CGRP in headache pathophysiology and sparked great interest in developing new treatment strategies using CGRP antagonists and antibodies. Future studies applying more refined human experimental models should identify biomarkers of CGRP-induced primary headache and reveal whether CGRP provocation experiments could be used to predict efficacy of CGRP antagonists in migraine patients.
引用
收藏
页码：353 / 360
页数：8
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