Synthesis of 3-morpholin-4-yl-1-(4-nitrophenyl)-5,6-dihydro-1H-pyridin-2-one

被引：0

作者：

Wang, Linxiao ^{[1
]}

Wang, Jianqiang ^{[2
]}

Xu, Shan ^{[1
]}

Wu, Jielian ^{[1
]}

Tang, Qidong ^{[1
]}

Zheng, Pengwu ^{[1
]}

机构：

[1] Jiangxi Sci & Technol Normal Univ, Sch Pharm, Nanchang 330013, Peoples R China

[2] Fushun Ctr Drug Contorl, Fushun, Peoples R China

来源：

PROCEEDINGS OF THE 2016 4TH INTERNATIONAL CONFERENCE ON MACHINERY, MATERIALS AND COMPUTING TECHNOLOGY | 2016年 / 60卷

关键词：

3-Morpholin-4-y l-1-( 4-nitropheny l)-5; 6-dihydro-1; H; -; pyridin-2-one; Synthesis; Cyclopentanone oxime; FACTOR XA; INHIBITORS;

D O I：

暂无

中图分类号：

TP [自动化技术、计算机技术];

学科分类号：

0812 ;

摘要：

3-Morpholin-4-yl-1-(4-nitrophenyl)-5,6-dihydro-1H-pyridin-2-one (1) is an important intermediate for the synthesis of many biologically active compounds. It was synthesized from cyclopentanone oxime (7) and 1-fluoro-4-nitrobenzene through three steps including rearrangement. Reaction, condensation and nucleophilic substitution reaction. The structure of the target compound 1 was confirmed by H-1 NMR and MS spectrum.

引用

页码：766 / 769

页数：4

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