Resting metabolic connectivity in prodromal Alzheimer's disease. A European Alzheimer Disease Consortium (EADC) project

被引：102

作者：

Morbelli, Silvia ^{[1
]}

Drzezga, Alex ^{[2
]}

Perneczky, Robert ^{[3
]}

Frisoni, Giovanni B. ^{[4
]}

Caroli, Anna ^{[4
,5
]}

van Berckel, Bart N. M. ^{[6
,7
]}

Ossenkoppele, Rik ^{[6
,7
]}

Guedj, Eric ^{[8
,9
]}

Didic, Mira ^{[10
]}

Brugnolo, Andrea ^{[11
]}

Sambuceti, Gianmario ^{[1
]}

Pagani, Marco ^{[12
,13
]}

Salmon, Eric ^{[14
]}

Nobili, Flavio ^{[11
]}

机构：

[1] San Martino Univ Hosp, Nucl Med Unit, Dept Internal Med, I-16132 Genoa, Italy

[2] Tech Univ Munich, Dept Nucl Med, Munich, Germany

[3] Tech Univ Munich, Dept Psychiat & Psychotherapy, Munich, Germany

[4] IRCCS S Giovanni Dio FBF, LENITEM Lab Epidemiol & Neuroimaging, Brescia, Italy

[5] Mario Negri Inst Pharmacol Res, Dept Biomed Engn, Med Imaging Unit, I-24100 Bergamo, Italy

[6] Vrije Univ Amsterdam, Med Ctr, Dept Nucl Med, Amsterdam, Netherlands

[7] Vrije Univ Amsterdam, Med Ctr, PET Res, Amsterdam, Netherlands

[8] Univ Mediterranee, INSERM, Assistance Publ Hop Marseille, Serv Cent Biophys & Med Nucl,Fac Med, Marseille, France

[9] Univ Mediterranee, INSERM, Assistance Publ Hop Marseille, Ctr Europaen Rech Imagerie Med CERIMED,Fac Med, Marseille, France

[10] Univ Mediterranee, Hop Timone, Assistance Publ Hop Marseille, Serv Neurol & Neuropsychol,Fac Med,INSERM,U751, Marseille, France

[11] San Martino Univ Hosp, Dept Neurosci Ophthalmol & Genet, Clin Neurophysiol Unit, I-16132 Genoa, Italy

[12] CNR, Inst Cognit Sci & Technol, Rome, Italy

[13] Karolinska Hosp, Dept Nucl Med, S-10401 Stockholm, Sweden

[14] Univ Liege, Cognit & Behav Neurosci Ctr, Liege, Belgium

来源：

NEUROBIOLOGY OF AGING | 2012年 / 33卷 / 11期

关键词：

Prodromal Alzheimer's disease; Positron emission tomography; Functional connectivity; MILD COGNITIVE IMPAIRMENT; MODE NETWORK ACTIVITY; DEFAULT-MODE; ALTERED INTERCORRELATIONS; NORMALIZATION TEMPLATE; SPATIAL NORMALIZATION; REGIONAL RATES; AMNESTIC MCI; FDG-PET; CORTEX;

D O I：

10.1016/j.neurobiolaging.2012.01.005

中图分类号：

R592 [老年病学]; C [社会科学总论];

学科分类号：

03 ; 0303 ; 100203 ;

摘要：

We explored resting-state metabolic connectivity in prodromal Alzheimer's disease (pAD) patients and in healthy controls (CTR), through a voxel-wise interregional correlation analysis of 18F-fluorodeoxyglucose (FDG)-positron emission tomography (PET) by means of statistical parametric mapping. Baseline 18F-fluorodeoxyglucose-positron emission tomography of 36 patients with amnestic mild cognitive impairment who converted to Alzheimer's disease (AD) dementia after an average time of 2 years (pAD) and of 105 CTR were processed. The area of hypometabolism in pAD showed less metabolic connectivity in patients than in CTR (autocorrelation and correlation with large temporal and frontal areas, respectively). pAD patients showed limited correlation even in selected nonhypometabolic areas, including the hippocampi and the dorsolateral prefrontal cortex (DLFC). On the contrary, in CTR group correlation was highlighted between hippocampi and precuneus/posterior cingulate and frontal cortex, and between dorsolateral prefrontal cortex and caudate nuclei and parietal cortex. The reduced metabolic connections both in hypometabolic and nonhypometabolic areas in pAD patients suggest that metabolic disconnection (reflecting early diaschisis) may antedate remote hypometabolism (early sign of synaptic degeneration). (c) 2012 Elsevier Inc. All rights reserved.

引用

页码：2533 / 2550

页数：18

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