Systematic Study of the Physicochemical Properties of a Homologous Series of Aminobisphosphonates

被引：32

作者：

Alanne, Aino-Liisa ^{[1
]}

Hyvonen, Helena ^{[2
]}

Lahtinen, Manu ^{[3
]}

Ylisirnio, Markku ^{[1
]}

Turhanen, Petri ^{[1
]}

Kolehmainen, Erkki ^{[3
]}

Peraniemi, Sirpa ^{[1
]}

Vepsalainen, Jouko ^{[1
]}

机构：

[1] Univ Eastern Finland, Sch Pharm, Bioctr Kuopio, FIN-70211 Kuopio, Finland

[2] Univ Helsinki, Dept Chem, Inorgan Chem Lab, FIN-00014 Helsinki, Finland

[3] Univ Jyvaskyla, Dept Chem, FIN-40014 Jyvaskyla, Finland

来源：

MOLECULES | 2012年 / 17卷 / 09期

基金：

芬兰科学院;

关键词：

bisphosphonates; aqueous solubility; pKa; physicochemical properties; BISPHOSPHONATES; ACIDS; COORDINATION; DERIVATIVES; ALENDRONATE; CRYSTAL; GROWTH; AGENTS;

D O I：

10.3390/molecules170910928

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Aminobisphosphonates, e. g., alendronate and neridronate, are a well known class of molecules used as drugs for various bone diseases. Although these molecules have been available for decades, a detailed understanding of their most important physicochemical properties under comparable conditions is lacking. In this study, ten aminobisphosphonates, H2N(CH2)(n)C(OH)[P(O)(OH)(2)](2), in which n = 2-5, 7-11 and 15 have been synthesized. Their aqueous solubility as a function of temperature and pH, pK(a)-values, thermal stability, IR absorptions, and NMR spectral data for both liquid (H-1, C-13, P-31-NMR) and solid state (C-13, N-15 and P-31-CPMAS NMR) were determined.

引用

页码：10928 / 10945

页数：18

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