Regio- and Stereoselective Oxidative Phenol Coupling in Aspergillus niger

被引：64

作者：

Girol, Christian Gil ^{[1
]}

Fisch, Katja M. ^{[2
]}

Heinekamp, Thorsten ^{[4
]}

Guenther, Stefan ^{[1
]}

Huettel, Wolfgang ^{[1
]}

Piel, Joern ^{[3
]}

Brakhage, Axel A. ^{[4
]}

Mueller, Michael ^{[1
]}

机构：

[1] Univ Freiburg, Inst Pharmazeut Wissensch, D-79104 Freiburg, Germany

[2] Univ Bristol, Sch Chem, Bristol BS8 1TS, Avon, England

[3] Univ Bonn, Kekule Inst Organ Chem & Biochem, D-53121 Bonn, Germany

[4] Leibniz Inst Nat Prod Res & Infect Biol, Dept Mol & Appl Microbiol, D-07745 Jena, Germany

来源：

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2012年 / 51卷 / 39期

关键词：

biaryls; biosynthesis; C?C coupling; natural products; polyketides; DIRIGENT PROTEIN; BICOUMARINS; KOTANIN; BIOSYNTHESIS; METABOLITES; SCLEROTIA; PRODUCTS; LACCASE; GENES;

D O I：

10.1002/anie.201203603

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Piecing it together: Aspergillus niger produces kotanin (see structure) by dimerization of the monomeric, polyketide-synthase-derived (PKS) 7-demethylsiderin. A combined approach, comprising bioinformatics and gene-deletion experiments, identified the biosynthetic cluster responsible for kotanin production. Homology modeling and substrate docking provide a rationale for the regio- and stereoselective phenol coupling reaction. Copyright © 2012 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

引用

页码：9788 / 9791

页数：4

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