Diagnosis and Management of Barrett's Esophagus

被引：14

作者：

Nelsen, Eric M. ^{[2
]}

Hawes, Robert H. ^{[3
]}

Iyer, Prasad G. ^{[1
]}

机构：

[1] Mayo Clin, Div Gastroenterol & Hepatol, Barretts Esophagus Unit, Rochester, MN 55905 USA

[2] Mayo Clin, Dept Internal Med, Rochester, MN 55905 USA

[3] Florida Hosp, Ctr Intervent Endoscopy, Orlando, FL 32803 USA

来源：

SURGICAL CLINICS OF NORTH AMERICA | 2012年 / 92卷 / 05期

基金：

美国国家卫生研究院;

关键词：

Esophageal adenocarcinoma; Screening; Pathogenesis; Management; Ablation; HIGH-GRADE DYSPLASIA; GASTROESOPHAGEAL-REFLUX DISEASE; NONSTEROIDAL ANTIINFLAMMATORY DRUGS; ENDOSCOPIC MUCOSAL RESECTION; ARGON PLASMA COAGULATION; COLUMNAR-LINED ESOPHAGUS; PROTON PUMP INHIBITORS; TERM-FOLLOW-UP; NEOPLASTIC PROGRESSION; PHOTODYNAMIC THERAPY;

D O I：

10.1016/j.suc.2012.07.009

中图分类号：

R61 [外科手术学];

学科分类号：

摘要：

Barrett esophagus is characterized by the replacement of squamous mucosa in the esophagus by specialized intestinal metaplasia. Its clinical significance lies in it being the strongest risk factor for and known precursor for esophageal adenocarcinoma. Diagnosis requires endoscopic confirmation of columnar metaplasia in the distal esophagus and histologic confirmation of specialized intestinal metaplasia. Recommendations for the management of subjects diagnosed with Barrett esophagus include periodic endoscopic surveillance to detect the development of high-grade dysplasia or adenocarcinoma. Careful endoscopic evaluation with high-resolution endoscopy and endoscopic resection is recommended in the evaluation of subjects with high-grade dysplasia and early adenocarcinoma.

引用

页码：1135 / +

页数：21

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