Genetic susceptibility to aminoglycoside ototoxicity

被引:31
作者
Nguyen, Tien [1 ]
Jeyakumar, Anita [2 ]
机构
[1] Virginia Tech, Corilion Sch Med, Roanoke, VA USA
[2] Akron Childrens Hosp, Dept Surg, Div Otolaryngol, Akron, OH 44308 USA
关键词
Aminoglycoside; Hearing loss; Ototoxicity; RIBOSOMAL-RNA GENE; LARGE CHINESE FAMILY; HEARING-LOSS; A1555G MUTATION; C1494T MUTATION; MITOCHONDRIAL; DEAFNESS; PREVALENCE; COSEGREGATION;
D O I
10.1016/j.ijporl.2019.02.002
中图分类号
R76 [耳鼻咽喉科学];
学科分类号
100213 ;
摘要
Introduction: Aminoglycosides are a well-known clinically relevant antibiotic family used to treat bacterial infections in humans and animals and can produce toxic side effects. Aminoglycoside-induced hearing loss (HL) has been shown to have a genetic susceptibility. Mitochondrial DNA mutations have been implicated in inherited and acquired hearing impairment. Objective: Literature review of genetic mutations associated with aminoglycoside-induced ototoxicity. Methods: PubMed was accessed from 1993 to 2017 using the search terms "aminoglycoside, genetic, ototoxicity, hearing loss". Exclusion criteria consisted of a literature in a language other than English, uncompleted or ongoing studies, literature with non-hearing related diseases, literature on ototoxicity due to cisplatin/carboplatin based chemotherapy, literature on ototoxicity from loop diuretics, animal studies, literature studying otoprotective agents, and literature without documented aminoglycoside exposure. Results: 108 articles were originally identified, and 25 articles were included in our review. Mitochondrial 12S rRNA mutations were identified in all 25 studies in a total of 220 patients. Eight studies identified A1555G mutation as primary genetic factor underlying HL in cases of aminoglycoside-induced ototoxicity. The next most common mutation identified was C1494T. Discussion: Mitochondrial 12s rRNA mutation A1555G was present in American, Chinese, Arab-Israeli, Spanish and Mongolian ethnicities. All mutations leading to aminoglycoside ototoxicity were mitochondrial mutations. Conclusions: Consideration of preexisting genetic defects may be valuable in treatments involving aminoglycosides. In particular populations such as those of Chinese origin, clinicians should continue to consider the increased susceptibility to aminoglycosides.
引用
收藏
页码:15 / 19
页数:5
相关论文
共 40 条
  • [1] [Anonymous], 2011, NEON FORM, P237
  • [2] [Anonymous], ACS demographic and housing estimates, 2019 ACS 5 -year estimates data profiles
  • [3] [Anonymous], 2013, Pocket book of hospital care for children: guidelines for the management of common childhood illnesses
  • [4] SUSCEPTIBILITY MUTATIONS IN THE MITOCHONDRIAL SMALL RIBOSOMAL-RNA GENE IN AMINOGLYCOSIDE INDUCED DEAFNESS
    BACINO, C
    PREZANT, TR
    BU, XD
    FOURNIER, P
    FISCHELGHODSIAN, N
    [J]. PHARMACOGENETICS, 1995, 5 (03): : 165 - 172
  • [5] Prevalence of Mitochondrial 1555A>G Mutation in European Children
    Bitner-Glindzicz, Maria
    Pembrey, Marcus
    Duncan, Andrew
    Heron, Jon
    Ring, Susan M.
    Hall, Amanda
    Rahman, Shamima
    [J]. NEW ENGLAND JOURNAL OF MEDICINE, 2009, 360 (06) : 640 - 642
  • [6] Gentamicin, genetic variation and deafness in preterm children
    Bitner-Glindzicz, Maria
    Rahman, Shamima
    Chant, Kathy
    Marlow, Neil
    [J]. BMC PEDIATRICS, 2014, 14
  • [7] Inherited susceptibility to aminoglycoside ototoxicity: Genetic heterogeneity and clinical implications
    Casano, RAMS
    Johnson, DF
    Bykhovskaya, Y
    Torricelli, F
    Bigozzi, M
    Fischel-Ghodsian, N
    [J]. AMERICAN JOURNAL OF OTOLARYNGOLOGY, 1999, 20 (03) : 151 - 156
  • [8] Maternally inherited aminoglycoside-induced and nonsyndromic hearing loss is associated with the 12S rRNA C1494T mutation in three Han Chinese pedigrees
    Chen, Jianfu
    Yang, Li
    Yang, Alfen
    Zhu, Yi
    Zhao, Jianyue
    Sun, Dongmei
    Tao, Zhlhua
    Tang, Xiaowen
    Wang, Jindan
    Wang, Xinjian
    Tsushima, Asami
    Lan, Jinshan
    Li, Weixing
    Wu, Fangli
    Yuan, Qian
    Ji, Jingzhang
    Feng, Jinbao
    Wu, Chunli
    Liao, Zhisu
    Li, Zhiyuan
    Greinwald, John H.
    Lu, Jianxin
    Guan, Min-Xin
    [J]. GENE, 2007, 401 (1-2) : 4 - 11
  • [9] The Prevalence of Mitochondrial Mutations Associated with Aminoglycoside-Induced Sensorineural Hearing Loss in an NICU Population
    Ealy, Megan
    Lynch, Katherine A.
    Meyer, Nicole C.
    Smith, Richard J. H.
    [J]. LARYNGOSCOPE, 2011, 121 (06) : 1184 - 1186
  • [10] A randomised, controlled trial of once daily and multi-dose daily gentamicin in young Kenyan infants
    English, M
    Mohammed, S
    Ross, A
    Ndirangu, S
    Kokwaro, G
    Shann, F
    Marsh, K
    [J]. ARCHIVES OF DISEASE IN CHILDHOOD, 2004, 89 (07) : 665 - 669