Normal hypocretin-1 (orexin-A) levels in the cerebrospinal fluid of patients with Huntington's disease

被引：31

作者：

Meier, A

Mollenhauer, B

Cohrs, S

Rodenbeck, A

Jordan, W

Meller, J

Otto, M

机构：

[1] Univ Gottingen, Dept Psychiat & Psychotherapy, Sleep Disorders Ctr, D-37075 Gottingen, Germany

[2] Univ Gottingen, Dept Neurol, D-3400 Gottingen, Germany

[3] Univ Gottingen, Dept Nucl Med, D-3400 Gottingen, Germany

来源：

BRAIN RESEARCH | 2005年 / 1063卷 / 02期

关键词：

hypocretin; Huntington; orexin;

D O I：

10.1016/j.brainres.2005.09.028

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

A significant atrophy and loss of hypocretin neurons in the brains of human patients with Huntington's disease (HD) and in R6/2 mice have been reported. We included 10 patients with HD and 12 patients with chorea-like hyperkinetic movement disorders (non-HD). All patients of the HD group and eleven patients of the non-HD group showed normal hypocretin-1 levels. Thus, hypocretin-1 may not serve as an additional diagnostic marker for HD. (C) 2005 Elsevier B.V. All rights reserved.

引用

页码：201 / 203

页数：3

共 12 条

[1] CSF hypocretin (Orexin) in neurological and psychiatric conditions
Ebrahim, IO
Semra, YK
De Lacy, S
Howard, RS
Kopelman, MD
Williams, A
Sharief, MK
[J]. JOURNAL OF SLEEP RESEARCH, 2003, 12 (01) : 83 - 84
[2] Huntington's disease:: pathomechanism and therapeutic perspectives
Gárdián, G
Vécsei, L
[J]. JOURNAL OF NEURAL TRANSMISSION, 2004, 111 (10-11) : 1485 - 1494
[3] CSF hypocretin-1 (orexin-A) concentrations in narcolepsy with and without cataplexy and idiopathic hypersomnia
Kanbayashi, T
Inoue, Y
Chiba, S
Aizawa, R
Saito, Y
Tsukamoto, H
Fujii, Y
Nishino, S
Shimizu, T
[J]. JOURNAL OF SLEEP RESEARCH, 2002, 11 (01) : 91 - 93
[4] A NOVEL GENE CONTAINING A TRINUCLEOTIDE REPEAT THAT IS EXPANDED AND UNSTABLE ON HUNTINGTONS-DISEASE CHROMOSOMES
MACDONALD, ME
AMBROSE, CM
DUYAO, MP
MYERS, RH
LIN, C
SRINIDHI, L
BARNES, G
TAYLOR, SA
JAMES, M
GROOT, N
MACFARLANE, H
JENKINS, B
ANDERSON, MA
WEXLER, NS
GUSELLA, JF
BATES, GP
BAXENDALE, S
HUMMERICH, H
KIRBY, S
NORTH, M
YOUNGMAN, S
MOTT, R
ZEHETNER, G
SEDLACEK, Z
POUSTKA, A
FRISCHAUF, AM
LEHRACH, H
BUCKLER, AJ
CHURCH, D
DOUCETTESTAMM, L
ODONOVAN, MC
RIBARAMIREZ, L
SHAH, M
STANTON, VP
STROBEL, SA
DRATHS, KM
WALES, JL
DERVAN, P
HOUSMAN, DE
ALTHERR, M
SHIANG, R
THOMPSON, L
FIELDER, T
WASMUTH, JJ
TAGLE, D
VALDES, J
ELMER, L
ALLARD, M
CASTILLA, L
SWAROOP, M
[J]. CELL, 1993, 72 (06) : 971 - 983
[5] The role of cerebrospinal fluid hypocretin measurement in the diagnosis of narcolepsy and other hypersomnias
Mignot, E
Lammers, GJ
Ripley, B
Okun, M
Nevsimalova, S
Overeem, S
Vankova, J
Black, J
Harsh, J
Bassetti, C
Schrader, H
Nishino, S
[J]. ARCHIVES OF NEUROLOGY, 2002, 59 (10) : 1553 - 1562
[6] Orexin loss in Huntington's disease
Petersén, Å
Gil, J
Björkqvist, M
Tanila, H
Araújo, IM
Smith, R
Popovic, N
Wierup, N
Norlén, P
Li, JY
Roos, RAC
Sundler, F
Mulder, H
Brundin, P
[J]. HUMAN MOLECULAR GENETICS, 2005, 14 (01) : 39 - 47
[7] Sleep and quantitative EEG in neurodegenerative disorders
Petit, D
Gagnon, JF
Fantini, ML
Ferini-Strambi, L
Montplaisir, J
[J]. JOURNAL OF PSYCHOSOMATIC RESEARCH, 2004, 56 (05) : 487 - 496
[8] Peyron C, 1998, J NEUROSCI, V18, P9996
[9] CSF hypocretin/orexin levels in narcolepsy and other neurological conditions
Ripley, B
Overeem, S
Fujiki, N
Nevsimalova, S
Uchino, M
Yesavage, J
Di Monte, D
Dohi, K
Melberg, A
Lammers, GJ
Nishida, Y
Roelandse, FWC
Hungs, M
Mignot, E
Nishino, S
[J]. NEUROLOGY, 2001, 57 (12) : 2253 - 2258
[10] Sutcliffe JG, 2000, J NEUROSCI RES, V62, P161, DOI 10.1002/1097-4547(20001015)62:2<161::AID-JNR1>3.0.CO

← 1 2 →