Normal hypocretin-1 (orexin-A) levels in the cerebrospinal fluid of patients with Huntington's disease

被引：31
|
作者：
Meier, A
Mollenhauer, B
Cohrs, S
Rodenbeck, A
Jordan, W
Meller, J
Otto, M
机构：
[1] Univ Gottingen, Dept Psychiat & Psychotherapy, Sleep Disorders Ctr, D-37075 Gottingen, Germany
[2] Univ Gottingen, Dept Neurol, D-3400 Gottingen, Germany
[3] Univ Gottingen, Dept Nucl Med, D-3400 Gottingen, Germany
来源：
BRAIN RESEARCH | 2005年 / 1063卷 / 02期
关键词：
hypocretin; Huntington; orexin;
D O I：
10.1016/j.brainres.2005.09.028
中图分类号：
Q189 [神经科学];
学科分类号：
071006 ;
摘要：
A significant atrophy and loss of hypocretin neurons in the brains of human patients with Huntington's disease (HD) and in R6/2 mice have been reported. We included 10 patients with HD and 12 patients with chorea-like hyperkinetic movement disorders (non-HD). All patients of the HD group and eleven patients of the non-HD group showed normal hypocretin-1 levels. Thus, hypocretin-1 may not serve as an additional diagnostic marker for HD. (C) 2005 Elsevier B.V. All rights reserved.
引用
收藏
页码：201 / 203
页数：3
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