Flow-Directed Assembly of Block Copolymer Vesicles in the Lab-on-a-Chip

被引：36

作者：

Wang, Chih-Wei ^{[1
]}

Bains, Aman ^{[1
]}

Sinton, David ^{[2
]}

Moffitt, Matthew G. ^{[1
]}

机构：

[1] Univ Victoria, Dept Chem, Victoria, BC V8W 3V6, Canada

[2] Univ Toronto, Dept Mech & Ind Engn, Toronto, ON M5S 3G8, Canada

来源：

LANGMUIR | 2012年 / 28卷 / 45期

基金：

加拿大创新基金会; 加拿大自然科学与工程研究理事会;

关键词：

SHEAR-FLOW; MICELLES; DIBLOCK; MORPHOLOGIES; PARTICLES;

D O I：

10.1021/la303655s

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

We demonstrate a microfluidic approach to the production of block copolymer vesicles via flow directed self assembly in a segmented gas-liquid device. Chemical conditions that favor spherical micelles in the bulk are found to yield a nearly pure population of vesicles on a chip-a transformation of two full morphological steps-because of a coalescence mechanism enabled by high shear. The production of polymeric vesicles via top-down control in a microfluidic device enables new processing routes to applications including drug delivery formulations in the lab-on-a-chip.

引用

页码：15756 / 15761

页数：6

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