Flow-Directed Assembly of Block Copolymer Vesicles in the Lab-on-a-Chip

被引：36
作者：
Wang, Chih-Wei [1 ]
Bains, Aman [1 ]
Sinton, David [2 ]
Moffitt, Matthew G. [1 ]
机构：
[1] Univ Victoria, Dept Chem, Victoria, BC V8W 3V6, Canada
[2] Univ Toronto, Dept Mech & Ind Engn, Toronto, ON M5S 3G8, Canada
来源：
LANGMUIR | 2012年 / 28卷 / 45期
基金：
加拿大创新基金会; 加拿大自然科学与工程研究理事会;
关键词：
SHEAR-FLOW; MICELLES; DIBLOCK; MORPHOLOGIES; PARTICLES;
D O I：
10.1021/la303655s
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
We demonstrate a microfluidic approach to the production of block copolymer vesicles via flow directed self assembly in a segmented gas-liquid device. Chemical conditions that favor spherical micelles in the bulk are found to yield a nearly pure population of vesicles on a chip-a transformation of two full morphological steps-because of a coalescence mechanism enabled by high shear. The production of polymeric vesicles via top-down control in a microfluidic device enables new processing routes to applications including drug delivery formulations in the lab-on-a-chip.
引用
收藏
页码：15756 / 15761
页数：6
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