Ent-kauren-19-oic acid derivatives from the stem bark of Croton pseudopulchellus Pax

被引：22
|
作者：
Langat, Moses K. [1 ,2 ]
Crouch, Neil R. [2 ,3 ]
Pohjala, Leena [4 ,5 ]
Tammela, Paivi [4 ]
Smith, Peter J. [6 ]
Mulholland, Dulcie A. [1 ,2 ]
机构：
[1] Univ Surrey, Div Chem Sci, Fac Hlth & Med Sci, Guildford GU2 7XH, Surrey, England
[2] Univ KwaZulu Natal, Sch Chem, ZA-4041 Durban, South Africa
[3] S African Natl Biodivers Inst, Ethnobot Unit, ZA-4007 Durban, South Africa
[4] Univ Helsinki, Fac Pharm, Ctr Drug Res, FI-00014 Helsinki, Finland
[5] Univ Helsinki, Fac Pharm, Div Pharmaceut Biol, FI-00014 Helsinki, Finland
[6] Univ Cape Town, Groote Schuur Hosp, Div Clin Pharmacol, Dept Med, ZA-7925 Cape Town, South Africa
来源：
PHYTOCHEMISTRY LETTERS | 2012年 / 5卷 / 03期
基金：
新加坡国家研究基金会;
关键词：
Euphorbiaceae; Croton pseudopulchellus; Ent-14S*-hydroxykaur-16-en-19-oic acid; Ent-14S*; 17-dihydroxykaur-15-en-19-oic acid; Ent-kaur-16-en-19-oic acid; Ent-kaur-16-en-19-al; Ent-12 beta-hydroxykaur-16-en-19-oic acid; Ent-12 beta-acetoxykaur-16-en-19-oic acid; 8R; 13R-epoxylabd-14-ene; Eudesm-4(15)-ene-1; beta; 6; alpha-diol; (-)-7-Epivaleran-4-one; Germacra-4(15); 5E; 10(14)-trien-9; beta-ol; Acetyl aleuritolic acid; beta-Amyrin; Semliki Forest virus; Huh-7 liver tumour cells; Plasmodium falciparum (CQS) D10 strain; BIOLOGICAL-ACTIVITIES; RABDOSIA-UMBROSA; DITERPENES; CYTOTOXICITY;
D O I：
10.1016/j.phytol.2012.03.002
中图分类号：
Q94 [植物学];
学科分类号：
071001 ;
摘要：
Two new ent-kauren-19-oic acid derivatives, ent-14S*-hydroxykaur-16-en-19-oic acid and ent-14S*,17dihydroxykaur-15-en-19-oic acid together with eleven known compounds ent-kaur-16-en-19-oic acid, ent-kaur-16-en-19-al, ent-12 beta-hydroxykaur-16-en-19-oic acid, ent-12 beta-acetoxykaur-16-en-19-oic acid, 8R, 13R-epoxylabd-14-ene, eudesm-4(15)-ene-1 beta,6 alpha-diol, (-)-7-epivaleran-4-one, germacra-4(15), 5E, 10(14)-trien-9 beta-ol, acetyl aleuritolic acid, beta-amyrin, and stigmasterol were isolated from the stem bark of Croton pseudopulchellus (Euphorbiaceae). Structures were determined using spectroscopic techniques. Ent-14S*-hydroxykaur-16-en-19-oic acid, ent-kaur-16-en-19-oic acid, ent-12 beta-hydroxykaur-16-en-19-oic acid, ent-12 beta-acetoxykaur-16-en-19-oic acid and 8R, 13R-epoxylabd-14- ene were tested for their effects on Semliki Forest virus replication and for cytotoxicity against human liver tumour cells (Huh-7 strain) but were found to be inactive. Ent-kaur-16-en-19-oic acid, the major constituent, showed weak activity against the Plasmodium falciparum (CQS) D10 strain. (C) 2012 Phytochemical Society of Europe. Published by Elsevier B.V. All rights reserved.
引用
收藏
页码：414 / 418
页数：5
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