Genoketides A1 and A2, new octaketides and biosynthetic intermediates of chrysophanol produced by Streptomyces sp AK 671

被引：9

作者：

Fiedler, Hans-Peter ^{[1
]}

Dieter, Anke ^{[1
]}

Guider, Tobias A. M. ^{[3
]}

Kajahn, Inga ^{[3
]}

Hamm, Andreas ^{[3
]}

Brown, Ros ^{[2
]}

Jones, Amanda L. ^{[2
]}

Goodfellow, Michael ^{[2
]}

Mueller, Werner E. G. ^{[4
]}

Bringmann, Gerhard ^{[3
]}

机构：

[1] Univ Tubingen, Inst Mikrobiol, D-72076 Tubingen, Germany

[2] Univ Newcastle, Sch Biol, Newcastle Upon Tyne NE1 7RU, Tyne & Wear, England

[3] Univ Wurzburg, Inst Organ Chem, D-97074 Wurzburg, Germany

[4] Johannes Gutenberg Univ Mainz, Inst Physiol Chem, Angew Mol Biol Abt, D-55099 Mainz, Germany

来源：

JOURNAL OF ANTIBIOTICS | 2008年 / 61卷 / 07期

关键词：

Streptomyces; octaketides; chrysophanol; fermentation; structure elucidation; antitumor activity;

D O I：

10.1038/ja.2008.63

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

The new aromatic polyketides genoketide A1, genoketide A2 and prechrysophanol glucuronide are biosynthetic intermediates of the octaketide chrysophanol. They were isolated from the alkaliphilic strain Streptomyces sp. AK 671 together with the new metabolite chrysophanol glucuronide. The structures of the compounds were elucidated by mass spectrometry and NMR methods. Genoketide A2 exhibited a slight and prechrysophanol glucuronide a more pronounced inhibition of the proliferation of L5178y lymphoma cells.

引用

页码：464 / 473

页数：10

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