Mobility impairment is associated with reduced microstructural integrity of the inferior and superior cerebellar peduncles in elderly with no clinical signs of cerebellar dysfunction

被引:21
作者
Cavallari, Michele [1 ,2 ]
Moscufo, Nicola [1 ]
Skudlarski, Pawel [3 ]
Meier, Dominik [1 ]
Panzer, Victoria P. [4 ]
Pearlson, Godfrey D. [3 ,5 ,6 ]
White, William B. [7 ]
Wolfson, Leslie [8 ]
Guttmann, Charles R. G. [1 ]
机构
[1] Harvard Univ, Brigham & Womens Hosp, Sch Med, Ctr Neurol Imaging,Dept Radiol, Boston, MA 02115 USA
[2] Univ Roma La Sapienza, Dipartimento Neurosci Salute Mentale & Organi Sen, I-00185 Rome, Italy
[3] Hartford Hosp, IOL, Olin Neuropsychiat Res Ctr, Hartford, CT 06115 USA
[4] Univ Connecticut, Ctr Hlth, Dept Community Med & Healthcare, Farmington, CT USA
[5] Yale Univ, Sch Med, Dept Psychiat, New Haven, CT USA
[6] Yale Univ, Sch Med, Dept Neurobiol, New Haven, CT USA
[7] Univ Connecticut, Ctr Hlth, Calhoun Cardiol Ctr, Div Hypertens & Clin Pharmacol, Farmington, CT USA
[8] Univ Connecticut, Ctr Hlth, Dept Neurol, Farmington, CT USA
关键词
Aging; Mobility; Cerebellar peduncles; Diffusion tensor imaging; WHITE-MATTER CHANGES; APPARENT DIFFUSION-COEFFICIENT; PROGRESSIVE SUPRANUCLEAR PALSY; OFFICE BLOOD-PRESSURE; SMALL VESSEL DISEASE; OLDER-PEOPLE; PARKINSONS-DISEASE; MULTIPLE-SCLEROSIS; SPATIAL STATISTICS; MOTOR FUNCTION;
D O I
10.1016/j.nicl.2013.02.003
中图分类号
R445 [影像诊断学];
学科分类号
100207 ;
摘要
While the cerebellum plays a critical role in motor coordination and control no studies have investigated its involvement in idiopathic mobility impairment in community-dwelling elderly. In this study we tested the hypothesis that structural changes in the cerebellar peduncles not detected by conventional magnetic resonance imaging are associated with reduced mobility performance. The analysis involved eighty-five subjects (age range: 75-90 years) who had no clinical signs of cerebellar dysfunction. Based on the short physical performance battery (SPPB) score, we defined mobility status of the subjects in the study as normal (score 11-12, n = 26), intermediate (score 9-10, n = 27) or impaired (score <9, n = 32). We acquired diffusion tensor imaging data to obtain indices of white matter integrity: fractional anisotropy (FA), mean diffusivity (MD), axial diffusivity (AD) and radial diffusivity (RD). Using a parcellation atlas, regional indices within the superior, middle, and inferior cerebellar peduncles (ICP, MCP, SCP) were calculated and their associations with mobility performance were analyzed. Subjects with impaired mobility showed reduced FA and AD values in the ICP and SCP but not in the MCP. The ICP-FA, ICP-AD and SCP-FA indices showed a significant association with the SPPB score. We also observed significant correlation between ICP-FA and walk time (r = -0.311, p = 0.004), as well as between SCP-AD and self-paced maximum walking velocity (r = 0.385, p = 0.003) and usual walking velocity (r = 0.400, p = 0.002). In logistic regression analysis ICP-FA and ICP-AD together explained 51% of the variability in the mobility status of a sample comprising the normal and impaired subgroups, and correctly classified more than three-quarters of those subjects. Our findings suggest that presence of microstructural damage, likely axonal, in afferent and efferent connections of the cerebellum contributes to the deterioration of motor performance in older people. (C) 2013 The Authors. Published by Elsevier Inc.
引用
收藏
页码:332 / 340
页数:9
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