Preliminary classification of nonmalignant B cell proliferation in Sjogren's syndrome: Perspectives on pathobiology and treatment based on an integrated clinico-pathologic and molecular study approach

A classification of nonmalignant lymphoproliferation in Sjogren's syndrome is presented, based on the results of international meetings regarding Sjogren's syndrome-associated lymphomagenesis and on our results of a clinico-pathologic and molecular study and long-term follow-up in well-characterized patients. Sjogren's syndrome pathobiology has similarities to hepatitis C virus-related B-cell lymphoproliferation. Antigen stimulation with the preferential expansion of rheumatoid factor-positive clones and specific immunoglobulin gene expression and recombination represent key biologic events in lymphoproliferation. This classification is based on the coupling of molecular and histological studies and may result in more selective treatment approaches. (C) 2001 Academic Press.