Multifunctional Fe3O4/TaOx Core/Shell Nanoparticles for Simultaneous Magnetic Resonance Imaging and X-ray Computed Tomography

被引：202

作者：

Lee, Nohyun ^{[3
,4
]}

Cho, Hye Rim ^{[1
,2
]}

Oh, Myoung Hwan ^{[3
,4
]}

Lee, Soo Hong ^{[3
,4
]}

Kim, Kangmin ^{[3
,4
]}

Kim, Byung Hyo ^{[3
,4
]}

Shin, Kwangsoo ^{[3
,4
]}

Ahn, Tae-Young ^{[5
]}

Choi, Jin Woo ^{[1
,2
]}

Kim, Young-Woon ^{[5
]}

Choi, Seung Hong ^{[1
,2
]}

Hyeon, Taeghwan ^{[3
,4
]}

机构：

[1] Seoul Natl Univ Hosp, Seoul 110744, South Korea

[2] Seoul Natl Univ, Med Res Ctr, Inst Radiat Med, Seoul 110744, South Korea

[3] Seoul Natl Univ, Inst Chem Proc, World Class Univ Program Chem Convergence Energy, Seoul 151744, South Korea

[4] Seoul Natl Univ, Sch Chem & Biol Engn, Seoul 151744, South Korea

[5] Seoul Natl Univ, Sch Mat Sci & Engn, Seoul 151744, South Korea

来源：

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY | 2012年 / 134卷 / 25期

基金：

新加坡国家研究基金会;

关键词：

COATED GOLD NANOPARTICLES; IN-VIVO; OXIDE NANOPARTICLES; CONTRAST AGENTS; CANCER; SEMICONDUCTOR; METASTASES; HYPOXIA; DESIGN; CELLS;

D O I：

10.1021/ja3016582

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Multimodal imaging is highly desirable for accurate diagnosis because it can provide complementary information from each imaging modality. In this study, a sol-gel reaction of tantalum(V) ethoxide in a microemulsion containing Fe3O4 nanoparticles (NPs) was used to synthesize multifunctional Fe3O4/TaOx core/shell NPs, which were biocompatible and exhibited a prolonged circulation time. When the NPs were intravenously injected, the tumor-associated vessel was observed using computed tomography (CT), and magnetic resonance imaging (MRI) revealed the high and low vascular regions of the tumor.

引用

页码：10309 / 10312

页数：4

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